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Observational Study
. 2018 Oct 26;13(10):e0206469.
doi: 10.1371/journal.pone.0206469. eCollection 2018.

Outcomes in dialysis versus conservative care for older patients: A prospective cohort analysis of stage 5 Chronic Kidney Disease

Maharajan Raman  1   2 , Rachel J Middleton  1   2 , Philip A Kalra  1   2 , Darren Green  1   2
Affiliations
Observational Study

Outcomes in dialysis versus conservative care for older patients: A prospective cohort analysis of stage 5 Chronic Kidney Disease

Maharajan Raman et al. PLoS One. .

Abstract

Background: The benefits of dialysis in older people with ESKD are not clear. We prospectively evaluated whether dialysis has survival advantage compared to conservative care (CC) in older people who were medically suitable for dialysis therapy.

Methods: This was a prospective observational study of CKD patients aged ≥75 years when eGFR first reached ≤15ml/min/1.73m2. Hazard ratios (HR) for death were compared between patients who chose dialysis versus conservative care (CC) from when first seen in pre-dialysis clinic (eGFR ≤15ml/min/1.73m2), and when initiation of dialysis was first considered (eGFR ≤10ml/min/1.73m2). Patients with co-morbidities likely to significantly reduce life expectancy such as advanced heart failure, advanced dementia, and malignancy, were excluded.

Results: There were 204 patients (123 dialysis, 81 CC). 115 went on to record eGFR of ≤10ml/min/1.73m2 (73 dialysis, 42 CC). The median survival from eGFR first ≤15ml/min/1.73m2 for the dialysis and CC groups were 42 (33-50) months and 31 (21-41) months. The adjusted hazard ratio (HR) for death in the dialysis group compared to CC was 0.61 (0.41-0.61, p = 0.01). The median survival from eGFR first ≤10ml/min/1.73m2 for dialysis and CC group were 36 (25-47) months and 12 (0-5) months. The adjusted HR for death in the dialysis group compared to CC was 0.36 (0.21-0.62, p <0.001).

Conclusion: Dialysis confers a survival benefit in older patients medically suitable for dialysis. This study is novel in being both prospective and in excluding patients with co-morbidities which may limit suitability for dialysis and life expectancy. A future focus on quality of life is needed to establish the true benefits of dialysis in older people.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Reasons for exclusion from the study.
Fig 2
Fig 2. Survival curve comparing dialysis with conservative care from the date of first outpatient eGFR ≤15 mL/min/1.73m2.
Adjusted for age, peripheral vascular disease, and living alone.
Fig 3
Fig 3. Survival curve comparing dialysis with conservative care from the date of first outpatient eGFR ≤10 mL/min/1.73m2.
Adjusted for age and peripheral vascular disease.
Fig 4
Fig 4. Survival curve comparing dialysis with conservative care during the period that eGFR was between ≤15 mL/min/1.73m2 and >10mL/min/1.73m2.
Adjusted for age, peripheral vascular disease, and living alone.
See this image and copyright information in PMC

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