Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Nov;36(4):739-750.
doi: 10.1016/j.ncl.2018.06.002.

Progressive Multifocal Leukoencephalopathy

Elena Grebenciucova  1 , Joseph R Berger  2
Affiliations
Review

Progressive Multifocal Leukoencephalopathy

Elena Grebenciucova et al. Neurol Clin. 2018 Nov.

Abstract

Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection that occurs in patients whose immune system is compromised either because of an underlying illness or an immunosuppressive medication. John Cunningham virus, prevalent in 60% or more of the adult population as a latent or persistent infection, is responsible for the syndrome of PML. This article reviews PML in association with the most common immunotherapies and discusses risk mitigation and monitoring strategies.

Keywords: John Cunningham virus; Opportunistic infection; Progressive multifocal leukoencephalopathy.

PubMed Disclaimer

LinkOut - more resources