A comprehensive understanding of the gut mucosal immune system in allergic inflammation

Daisuke Tokuhara¹, Yosuke Kurashima², Mariko Kamioka³, Toshinori Nakayama⁴, Peter Ernst⁵, Hiroshi Kiyono⁶

Affiliations

¹ Department of Mucosal Immunology, IMSUT Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Gastroenterology, Department of Medicine, CU-UCSD Center for Mucosal Immunology, Allergy and Vaccines, University of California San Diego, San Diego, CA, USA; Division of Comparative Pathology and Medicine, Department of Pathology, University of California San Diego, San Diego, CA, USA; Department of Pediatrics, Osaka City University Graduate School of Medicine, Osaka, Japan.
² Department of Mucosal Immunology, IMSUT Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Gastroenterology, Department of Medicine, CU-UCSD Center for Mucosal Immunology, Allergy and Vaccines, University of California San Diego, San Diego, CA, USA; Department of Mucosal Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan; Department of Innovative Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan; Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
³ Department of Mucosal Immunology, IMSUT Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Gastroenterology, Department of Medicine, CU-UCSD Center for Mucosal Immunology, Allergy and Vaccines, University of California San Diego, San Diego, CA, USA.
⁴ Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
⁵ Division of Gastroenterology, Department of Medicine, CU-UCSD Center for Mucosal Immunology, Allergy and Vaccines, University of California San Diego, San Diego, CA, USA; Division of Comparative Pathology and Medicine, Department of Pathology, University of California San Diego, San Diego, CA, USA; Center for Veterinary Sciences and Comparative Medicine, University of California, San Diego, CA, USA.
⁶ Department of Mucosal Immunology, IMSUT Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Gastroenterology, Department of Medicine, CU-UCSD Center for Mucosal Immunology, Allergy and Vaccines, University of California San Diego, San Diego, CA, USA; Division of Comparative Pathology and Medicine, Department of Pathology, University of California San Diego, San Diego, CA, USA. Electronic address: kiyono@ims.u-tokyo.ac.jp.

PMID: 30366757
DOI: 10.1016/j.alit.2018.09.004

Review

A comprehensive understanding of the gut mucosal immune system in allergic inflammation

Daisuke Tokuhara et al. Allergol Int. 2019 Jan.

. 2019 Jan;68(1):17-25.

doi: 10.1016/j.alit.2018.09.004. Epub 2018 Oct 23.

Authors

Daisuke Tokuhara¹, Yosuke Kurashima², Mariko Kamioka³, Toshinori Nakayama⁴, Peter Ernst⁵, Hiroshi Kiyono⁶

Affiliations

¹ Department of Mucosal Immunology, IMSUT Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Gastroenterology, Department of Medicine, CU-UCSD Center for Mucosal Immunology, Allergy and Vaccines, University of California San Diego, San Diego, CA, USA; Division of Comparative Pathology and Medicine, Department of Pathology, University of California San Diego, San Diego, CA, USA; Department of Pediatrics, Osaka City University Graduate School of Medicine, Osaka, Japan.
² Department of Mucosal Immunology, IMSUT Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Gastroenterology, Department of Medicine, CU-UCSD Center for Mucosal Immunology, Allergy and Vaccines, University of California San Diego, San Diego, CA, USA; Department of Mucosal Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan; Department of Innovative Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan; Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
³ Department of Mucosal Immunology, IMSUT Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Gastroenterology, Department of Medicine, CU-UCSD Center for Mucosal Immunology, Allergy and Vaccines, University of California San Diego, San Diego, CA, USA.
⁴ Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
⁵ Division of Gastroenterology, Department of Medicine, CU-UCSD Center for Mucosal Immunology, Allergy and Vaccines, University of California San Diego, San Diego, CA, USA; Division of Comparative Pathology and Medicine, Department of Pathology, University of California San Diego, San Diego, CA, USA; Center for Veterinary Sciences and Comparative Medicine, University of California, San Diego, CA, USA.
⁶ Department of Mucosal Immunology, IMSUT Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Gastroenterology, Department of Medicine, CU-UCSD Center for Mucosal Immunology, Allergy and Vaccines, University of California San Diego, San Diego, CA, USA; Division of Comparative Pathology and Medicine, Department of Pathology, University of California San Diego, San Diego, CA, USA. Electronic address: kiyono@ims.u-tokyo.ac.jp.

PMID: 30366757
DOI: 10.1016/j.alit.2018.09.004

Abstract

Despite its direct exposure to huge amounts of microorganisms and foreign and dietary antigens, the gut mucosa maintains intestinal homeostasis by utilizing the mucosal immune system. The gut mucosal immune system protects the host from the invasion of infectious pathogens and eliminates harmful non-self antigens, but it allows the cohabitation of commensal bacteria in the gut and the entry of dietary non-self antigens into the body via the mucosal surface. These physiological and immunological activities are regulated by the ingenious gut mucosal immune network, comprising such features as gut-associated lymphoid tissue, mucosal immune cells, cytokines, chemokines, antimicrobial peptides, secretory IgA, and commensal bacteria. The gut mucosal immune network keeps a fine tuned balance between active immunity (against pathogens and harmful non-self antigens) and immune tolerance (to commensal microbiota and dietary antigens), thus maintaining intestinal healthy homeostasis. Disruption of gut homeostasis results in persistent or severe gastrointestinal infection, inflammatory bowel disease, or allergic inflammation. In this review, we comprehensively introduce current knowledge of the gut mucosal immune system, focusing on its interaction with allergic inflammation.

Keywords: Allergy; Microbiota; Mucosal immunity; Oral tolerance; Regulatory T cell.

PubMed Disclaimer

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

LinkOut - more resources

Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

A comprehensive understanding of the gut mucosal immune system in allergic inflammation

Affiliations

A comprehensive understanding of the gut mucosal immune system in allergic inflammation

Authors

Affiliations

Abstract

Publication types

MeSH terms

Substances

LinkOut - more resources

Medical