Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Dec;28(12):1127-1128.
doi: 10.1038/s41422-018-0105-8.

New roles for RAD52 in DNA repair

Chaoyou Xue  1 , Eric C Greene  2
Affiliations
Comment

New roles for RAD52 in DNA repair

Chaoyou Xue et al. Cell Res. 2018 Dec.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Transcription-associated homologous recombination repair. DSBs that form in transcriptionally inactive regions of the genome are repaired by NHEJ, which has the potential to introduce mutations or chromosome rearrangement (left panel). In contrast, transcriptionally active regions are repaired by error-free HR, which involves recognition of R-loops by RAD52 and also requires the participation of BRCA1, CtIP and XPG (right panel)
See this image and copyright information in PMC

Comment on

References

    1. Skourti-Stathaki K, Proudfoot NJ. Genes Dev. 2014;28:1384–1396. doi: 10.1101/gad.242990.114. - DOI - PMC - PubMed
    1. Ohle C, et al. Cell. 2016;167:1001–1013. doi: 10.1016/j.cell.2016.10.001. - DOI - PubMed
    1. Keskin H, et al. Nature. 2014;515:436–439. doi: 10.1038/nature13682. - DOI - PMC - PubMed
    1. McDevitt S, et al. Nat. Commun. 2018;9:1091. doi: 10.1038/s41467-018-03483-7. - DOI - PMC - PubMed
    1. Yasuhara T, et al. Cell. 2018;175:558–570. doi: 10.1016/j.cell.2018.08.056. - DOI - PubMed

Substances