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Review
. 2019 Jan;85(2):146-154.
doi: 10.1038/s41390-018-0214-6. Epub 2018 Oct 26.

Cortical interneuron function in autism spectrum condition

Jason W Lunden  1 , Madel Durens  1 , Andre W Phillips  1 , Michael W Nestor  2
Affiliations
Review

Cortical interneuron function in autism spectrum condition

Jason W Lunden et al. Pediatr Res. 2019 Jan.

Abstract

Cortical interneurons (INs) are a diverse group of neurons that project locally and shape the function of neural networks throughout the brain. Multiple lines of evidence suggest that a proper balance of glutamate and GABA signaling is essential for both the proper function and development of the brain. Dysregulation of this system may lead to neurodevelopmental disorders, including autism spectrum condition (ASC). We evaluate the development and function of INs in rodent and human models and examine how neurodevelopmental dysfunction may produce core symptoms of ASC. Finding common physiological mechanisms that underlie neurodevelopmental disorders may lead to novel pharmacological targets and candidates that could improve the cognitive and emotional symptoms associated with ASC.

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