Advances in coronary molecular imaging: Leveraging the power of image processing

Abstract

Coronary vascular events are most often caused by rupture of atherosclerotic plaques. Prior to their rupture, such plaques are likely to have at least one of several high-risk structural or biological processes known to associate with increased risk of atherothrombosis. Thus, efforts have long been directed to identify these high risk features non-invasively. While current imaging modalities are adept at measuring high-risk structural features, such as luminal stenosis and vessel wall morphology, they cannot directly report on the important high-risk biological features. On the other hand, molecular imaging techniques, such as positron emission tomography (PET) coupled with sensitive probes provide a unique opportunity to assess atherosclerotic plaque biology, and have the potential to complement structural information and thus, improve risk stratification and enable enhanced monitoring of therapeutic interventions.