Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Jul 1;166(1):259-64.
doi: 10.1084/jem.166.1.259.

Inducibility of Ia antigen on astrocytes by murine coronavirus JHM is rat strain dependent

P T Massa, R Brinkmann, V ter Meulen

Inducibility of Ia antigen on astrocytes by murine coronavirus JHM is rat strain dependent

P T Massa et al. J Exp Med. .

Abstract

Inducibility of Ia molecules on cultivated astrocytes by JHM virus correlates with demyelinating disease susceptibility of animals from which these astrocytes are derived. On the contrary, class I induction of both astrocytes and oligodendrocytes occurs as a consequence of normal cultivation procedures in both susceptible and resistant strains. Increased expression of class I antigens on rat astrocytes and oligodendrocytes is not related to JHM viral infection as it is in the mouse. These data indicate that strain differences in Ia inducibility, rather than inducibility of class I antigens, by JHM virus may explain higher levels of T cell-mediated damage to myelin during infection in susceptible rat strains compared with resistant strains.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Eur J Immunol. 1979 Jun;9(6):426-33 - PubMed
    1. J Neuroimmunol. 1987 Jan;13(3):259-71 - PubMed
    1. Brain Res. 1981 Jan 12;204(2):339-51 - PubMed
    1. Proc Natl Acad Sci U S A. 1982 Apr;79(8):2709-13 - PubMed
    1. Eur J Immunol. 1982 Mar;12(3):237-43 - PubMed

MeSH terms

Substances