doi: 10.1084/jem.166.2.341.
A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types
- PMID: 3036997
- PMCID: PMC2189607
- DOI: 10.1084/jem.166.2.341
Item in Clipboard
A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types
J Exp Med.
.
Abstract
We have previously described the isolation of pH-2d-37, a cDNA clone that encodes a so far unknown, poorly polymorphic, class I surface molecule. We report here the isolation of the corresponding gene, its nucleotide sequence, and its localization in the Tla region of the murine MHC. Using a RNase mapping assay, we have confirmed that the second domain coding region of the 37 gene displays very limited polymorphism, and that the gene is transcribed in a broad variety of cell types, in contrast to the genes encoding the known Qa and TL antigens. Possible functions are discussed.
Similar articles
-
Conservation and diversity in the class I genes of the major histocompatibility complex: sequence analysis of a Tlab gene and comparison with a Tlac gene.Proc Natl Acad Sci U S A. 1986 Mar;83(6):1782-6. doi: 10.1073/pnas.83.6.1782. Proc Natl Acad Sci U S A. 1986. PMID: 3456611 Free PMC article.
-
Evolution and expression of the transplantation antigen gene family.Fed Proc. 1985 Aug;44(11):2736-40. Fed Proc. 1985. PMID: 3926542
-
Structure of a gene encoding a murine thymus leukemia antigen, and organization of Tla genes in the BALB/c mouse.J Exp Med. 1985 Aug 1;162(2):528-45. doi: 10.1084/jem.162.2.528. J Exp Med. 1985. PMID: 3894562 Free PMC article. Review.
-
Expression of hybrid class I genes of the major histocompatibility complex in mouse L cells.Proc Natl Acad Sci U S A. 1985 Sep;82(18):6245-9. doi: 10.1073/pnas.82.18.6245. Proc Natl Acad Sci U S A. 1985. PMID: 3862131 Free PMC article.
-
An unusual class II molecule.Immunol Today. 1992 Dec;13(12):469-70. doi: 10.1016/0167-5699(92)90018-3. Immunol Today. 1992. PMID: 1463576 Review.
Cited by
-
Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway.Immunity. 2007 May;26(5):593-604. doi: 10.1016/j.immuni.2007.03.017. Immunity. 2007. PMID: 17509909 Free PMC article.
-
Genetic and molecular mapping of the Hmt region of mouse.EMBO J. 1989 Dec 1;8(12):3749-57. doi: 10.1002/j.1460-2075.1989.tb08551.x. EMBO J. 1989. PMID: 2573520 Free PMC article.
-
Fine map of a region homologous to the rat grc complex in the TL region of the mouse.Immunogenetics. 1993;37(5):386-9. doi: 10.1007/BF00216804. Immunogenetics. 1993. PMID: 8428772 No abstract available.
-
Independent gene duplications, not concerted evolution, explain relationships among class I MHC genes of murine rodents.Immunogenetics. 1991;33(5-6):367-73. doi: 10.1007/BF00216696. Immunogenetics. 1991. PMID: 2050391
-
Cloning and expression of class I major histocompatibility complex genes of the rat.J Exp Med. 1992 Jun 1;175(6):1749-57. doi: 10.1084/jem.175.6.1749. J Exp Med. 1992. PMID: 1588292 Free PMC article.
References
Publication types
MeSH terms
Substances
Associated data
- Actions
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
