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. 1987 Aug 1;166(2):341-61.
doi: 10.1084/jem.166.2.341.

A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types

C Transy, S R Nash, B David-Watine, M Cochet, S W Hunt 3rd, L E Hood, P Kourilsky

A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types

C Transy et al. J Exp Med. .

Abstract

We have previously described the isolation of pH-2d-37, a cDNA clone that encodes a so far unknown, poorly polymorphic, class I surface molecule. We report here the isolation of the corresponding gene, its nucleotide sequence, and its localization in the Tla region of the murine MHC. Using a RNase mapping assay, we have confirmed that the second domain coding region of the 37 gene displays very limited polymorphism, and that the gene is transcribed in a broad variety of cell types, in contrast to the genes encoding the known Qa and TL antigens. Possible functions are discussed.

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References

    1. J Immunol. 1981 Jul;127(1):293-300 - PubMed
    1. Proc Natl Acad Sci U S A. 1980 Jun;77(6):3201-5 - PubMed
    1. Cell. 1981 Sep;25(3):683-92 - PubMed
    1. Nature. 1982 Mar 18;296(5854):260-2 - PubMed
    1. Cell. 1982 Mar;28(3):489-98 - PubMed

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