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Editorial
. 2018 Sep;6(18):372.
doi: 10.21037/atm.2018.07.26.

Protecting functional β cells with a therapeutic peptide

Meghan L Marré  1 , Jon D Piganelli  1 , Eddie A James  2
Affiliations
Editorial

Protecting functional β cells with a therapeutic peptide

Meghan L Marré et al. Ann Transl Med. 2018 Sep.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Doc2b sequesters Munc18 to facilitate SNARE complex formation and insulin secretion. Individual SNARE proteins are anchored in the two membranes. t-SNARE proteins, syntaxin and SNAP25 reside in the plasma membrane, and v-SNARE protein, VAMP, resides in the insulin granule membrane. Munc18 proteins bind the t-SNARE and v-SNARE proteins with high affinity, inhibiting SNARE complex formation. Doc2b competes with SNARE proteins and binds to Munc18 proteins, releasing the t-SNARE and v-SNARE proteins for complex formation, allowing granule fusion with the plasma membrane and insulin secretion. t-SNARE, Target membrane SNARE; v-SNARE, vesicle-associated SNARE; SNAP25, synaptosomal-associated protein 25; VAMP, vesicle-associated membrane protein; Doc2b, double C2-domain protein β.
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