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. 2018 Aug 10:10:545-553.
doi: 10.1016/j.dadm.2018.07.001. eCollection 2018.

Apolipoproteins and Alzheimer's pathophysiology

Manja Koch  1 , Steven T DeKosky  2 , Annette L Fitzpatrick  3 , Jeremy D Furtado  1 , Oscar L Lopez  4 , Lewis H Kuller  5 , Rachel H Mackey  3 , Timothy M Hughes  6 , Kenneth J Mukamal  1   7 , Majken K Jensen  1   8
Affiliations

Apolipoproteins and Alzheimer's pathophysiology

Manja Koch et al. Alzheimers Dement (Amst). .

Abstract

Introduction: Apolipoproteins of demonstrated importance to brain cholesterol and ß-amyloid metabolism may serve as novel risk markers for Alzheimer's pathology.

Methods: We measured apolipoproteins (apoE, apoJ, apoA-I, and apoC-III and their uniquely defined subspecies) by enzyme-linked immunosorbent assay in plasma collected in 2000 and 2008 from 176 dementia-free participants of the Ginkgo Evaluation of Memory Study and related these to ß-amyloid on positron emission tomography scans, hippocampal volume, and white matter lesion volume in 2009.

Results: Higher apoE was associated with lower ß-amyloid deposition. Despite apoA-I being unrelated to hippocampal volume, subspecies of apoA-I containing or lacking apoJ or apoC-III showed opposite associations with hippocampal volume. Higher apoJ and apoE lacking apoJ were associated with higher hippocampal volume and higher white matter lesion volume, respectively. Associations were similar in participants without cognitive impairment or APOE ε4 noncarrier and when analyzing apolipoproteins in 2000-2002.

Discussion: Apolipoproteins may be important minimally invasive biomarkers indicative of Alzheimer's pathology.

Keywords: Apolipoproteins; Brain amyloid; Epidemiology; High-density lipoproteins; Neuroimaging.

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Figures

Fig. 1
Fig. 1
Measurement of apolipoproteins and apolipoprotein subspecies. Here, apoE in HDL containing or lacking apoJ was measured by a modified sandwich enzyme-linked immunosorbent assay approach (values are means). When measuring any apolipoprotein subspecies in the HDL fraction of plasma, apoB-containing lipoproteins are first removed. Abbreviations: HDLs, high-density lipoproteins; apo, apolipoproteins.
See this image and copyright information in PMC

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