AR-V7 and treatment selection in advanced prostate cancer: are we there yet?
- PMID: 30370427
- PMCID: PMC6201248
- DOI: 10.21037/pcm.2018.09.01
AR-V7 and treatment selection in advanced prostate cancer: are we there yet?
Conflict of interest statement
Conflicts of Interest: ES Antonarakis has served as a paid consultant/advisor for Janssen, Astellas, Sanofi, Dendreon, Merck, Essa, and Medivation; has received research funding to his institution from Janssen, Johnson & Johnson, Medivation, Sanofi, Dendreon, Bristol Myers Squibb, Genentech, Novartis, Bayer and Tokai; and is a co-inventor of an AR-V7 biomarker technology that has been licensed to Qiagen. DA Bastos has served as a paid consultant/advisor for Janssen, Astellas, Sanofi, Merck, and Roche; and has received research funding to his institution from Janssen.
Comment on
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Assessment of the Validity of Nuclear-Localized Androgen Receptor Splice Variant 7 in Circulating Tumor Cells as a Predictive Biomarker for Castration-Resistant Prostate Cancer.JAMA Oncol. 2018 Sep 1;4(9):1179-1186. doi: 10.1001/jamaoncol.2018.1621. JAMA Oncol. 2018. PMID: 29955787 Free PMC article.
References
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- Sartor O, de Bono JS. Metastatic Prostate Cancer. N Engl J Med 2018;378:645–57. - PubMed
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- Antonarakis ES, Lu C, Luber B, et al. Clinical Significance of Androgen Receptor Splice Variant-7 mRNA Detection in Circulating Tumor Cells of Men With Metastatic Castration-Resistant Prostate Cancer Treated With First- and Second-Line Abiraterone and Enzalutamide. J Clin Oncol 2017;35:2149–56. - PMC - PubMed
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