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. 2019 Feb;23(2):1598-1601.
doi: 10.1111/jcmm.13989. Epub 2018 Oct 28.

Significance of plasma MACC1 levels on the prognostic stratification in patients with colorectal cancer

Aifen Lin  1   2 , Rui-Li Zhang  2 , Xia Zhang  1 , Xiao-Fang He  3 , Jian-Gang Zhang  1 , Wei-Hua Yan  4
Affiliations

Significance of plasma MACC1 levels on the prognostic stratification in patients with colorectal cancer

Aifen Lin et al. J Cell Mol Med. 2019 Feb.

Abstract

The clinical significance of metastasis-associated in colon cancer-1 (MACC1) has been investigated but the relevance of peripheral MACC1 levels was rather limited. Herein, our data revealed that plasma MACC1 levels in 117 colorectal cancer patients (CRC) were dramatically higher than that in normal controls (P < 0.001), and with a strong discrimination power between the two groups (AUC = 0.960, P < 0.001). Moreover, MACC1 is an independent prognostic factor for CRC patients. When clinical parameters stratified by MACC1low and MACC1high , MACC1 levels exhibited further significant predictive value. Summary, plasma MACC1 levels could be a useful prognostic and diagnostic biomarker, and could improve the prognostic value of traditional prognosticators for colorectal cancer patients.

Keywords: MACC1; colorectal cancer; diagnosis; prognosis.

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Figures

Figure 1
Figure 1
A, ROC curve analysis for the performance of plasma MACC1 to distinguish CRC patients from normal controls. B, Comparison of the overall survival between the CRC patients with plasma MACC1high (n = 58) and MACC1low (n = 58) by Kaplan‐Meier survival analysis
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