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Review
. 2018 Oct 29;22(1):276.
doi: 10.1186/s13054-018-2185-8.

Vitamin D deficiency and supplementation in critical illness-the known knowns and known unknowns

Priya Nair  1   2   3   4   5 , Balasubramaniam Venkatesh  6   7   8   9 , Jacqueline R Center  10   11   12
Affiliations
Review

Vitamin D deficiency and supplementation in critical illness-the known knowns and known unknowns

Priya Nair et al. Crit Care. .

Abstract

The burgeoning literature on vitamin D deficiency and supplementation over the past decade or so has generated a greater understanding of some areas but also an appreciation of the many areas of equipoise. This is particularly relevant in the field of critical care with the heterogeneous patient populations, the severity and duration of illness and the frequency of comorbid conditions.This review aims to summarise the current knowledge base of vitamin D deficiency within the context of critical illness-"the known knowns"-and also highlight the areas of recognised uncertainty-"the known unknowns". It acknowledges the fact that there may well be other knowledge gaps of clinical relevance of which we are currently unaware-"the unknown unknowns".

Keywords: Cholecalciferol; Pleiotropic effects; Supplementation; Vitamin D; Vitamin D binding protein.

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Figures

Fig. 1
Fig. 1
Synthesis, metabolism and functions of vitamin D. PTH parathyroid hormone, FGF-23 fibroblast growth factor-23, RANKL receptor activator of nuclear kappa-B ligand
See this image and copyright information in PMC

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References

    1. Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014;21(3):319–329. doi: 10.1016/j.chembiol.2013.12.016. - DOI - PMC - PubMed
    1. Bikle D. Nonclassic actions of vitamin D. J Clin Endocrinol Metab. 2009;94(1):26–34. doi: 10.1210/jc.2008-1454. - DOI - PMC - PubMed
    1. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266–281. doi: 10.1056/NEJMra070553. - DOI - PubMed
    1. Norman AW. From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr. 2008;88(2):491S–499S. doi: 10.1093/ajcn/88.2.491S. - DOI - PubMed
    1. Ray R, Banks M, Abuzahra H, Eddy VJ, Persons KS, Lucia MS, et al. Effect of dietary vitamin D and calcium on the growth of androgen-insensitive human prostate tumor in a murine model. Anticancer Res. 2012;32(3):727–731. - PMC - PubMed

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