Renal Cell Carcinoma in the Era of Precision Medicine: From Molecular Pathology to Tissue-Based Biomarkers
- PMID: 30372384
- PMCID: PMC6299340
- DOI: 10.1200/JCO.2018.79.2259
Renal Cell Carcinoma in the Era of Precision Medicine: From Molecular Pathology to Tissue-Based Biomarkers
Abstract
Renal cell carcinoma (RCC) is not a single entity but includes various tumor subtypes that have been identified on the basis of either characteristic pathologic features or distinctive molecular changes. Clear cell RCC is the most common type of RCC and is characterized by dysregulation of the von Hippel Lindau/hypoxia-inducible factor pathway. Non-clear cell RCC represents a more heterogeneous group of tumors with diverse histopathologic and molecular features. In the past two decades, the improved understanding of the molecular landscape of RCC has led to the development of more effective therapies for metastatic RCC, which include both targeted agents and immune checkpoint inhibitors. Because only subsets of patients with metastatic RCC respond to a given treatment, predictive biomarkers are needed to guide treatment selection and sequence. In this review, we describe the key histologic features and molecular alterations of RCC subtypes and discuss emerging tissue-based biomarkers of response to currently available therapies for metastatic disease.
Similar articles
-
MicroRNAs Associated with Von Hippel-Lindau Pathway in Renal Cell Carcinoma: A Comprehensive Review.Int J Mol Sci. 2017 Nov 22;18(11):2495. doi: 10.3390/ijms18112495. Int J Mol Sci. 2017. PMID: 29165391 Free PMC article. Review.
-
Genetic pathways involved in carcinogenesis of clear cell renal cell carcinoma: genomics towards personalized medicine.BJU Int. 2012 Jun;109(12):1864-70. doi: 10.1111/j.1464-410X.2011.10661.x. Epub 2011 Oct 28. BJU Int. 2012. PMID: 22035299 Review.
-
Identification and validation of novel prognostic markers in Renal Cell Carcinoma.Dan Med J. 2017 Oct;64(10):B5339. Dan Med J. 2017. PMID: 28975890
-
Impact of tivozanib on patient outcomes in treatment of advanced renal cell carcinoma.Cancer Manag Res. 2019 Aug 16;11:7779-7785. doi: 10.2147/CMAR.S206105. eCollection 2019. Cancer Manag Res. 2019. PMID: 31496820 Free PMC article.
-
Clear Cell Papillary Renal Cell Carcinoma: A Recent Entity With Distinct Imaging Patterns.AJR Am J Roentgenol. 2020 Mar;214(3):579-587. doi: 10.2214/AJR.19.21681. Epub 2019 Nov 26. AJR Am J Roentgenol. 2020. PMID: 31770020
Cited by
-
Identification and Validation of Cuproptosis-Related LncRNA Signatures in the Prognosis and Immunotherapy of Clear Cell Renal Cell Carcinoma Using Machine Learning.Biomolecules. 2022 Dec 16;12(12):1890. doi: 10.3390/biom12121890. Biomolecules. 2022. PMID: 36551318 Free PMC article.
-
Outcomes for Atypical Tumor Recurrences Following Minimally Invasive Kidney Cancer Operations.Eur Urol Open Sci. 2022 May 6;40:125-132. doi: 10.1016/j.euros.2022.04.005. eCollection 2022 Jun. Eur Urol Open Sci. 2022. PMID: 35638088 Free PMC article.
-
Systematic Review of PD-1/PD-L1 Inhibitors in Oncology: From Personalized Medicine to Public Health.Oncologist. 2021 Oct;26(10):e1786-e1799. doi: 10.1002/onco.13887. Epub 2021 Jul 27. Oncologist. 2021. PMID: 34196068 Free PMC article.
-
Overexpression of SPHK1 associated with targeted therapy resistance in predicting poor prognosis in renal cell carcinoma.Transl Cancer Res. 2023 Mar 31;12(3):572-584. doi: 10.21037/tcr-22-417. Epub 2023 Feb 22. Transl Cancer Res. 2023. PMID: 37033345 Free PMC article.
-
Anti-Vascular Endothelial Growth Factor C Antibodies Efficiently Inhibit the Growth of Experimental Clear Cell Renal Cell Carcinomas.Cells. 2021 May 17;10(5):1222. doi: 10.3390/cells10051222. Cells. 2021. PMID: 34067671 Free PMC article.
References
-
- Kovacs G, Akhtar M, Beckwith BJ, et al. : The Heidelberg classification of renal cell tumours. J Pathol 183:131-133, 1997 - PubMed
-
- Eble JN, Sauter G, Epstein JI, et al. WHO Classification of Tumours of the Urinary System and Male Genital Organs (ed3). Lyon, France, IARC Press, 2004
-
- Moch H, Humphrey PA, Ulbright TM, et al. WHO Classification of Tumours of the Urinary System and Male Genital Organs (ed 4). Lyon, France, IARC, 2016 - PubMed
-
- Reuter VE, Tickoo SK: Differential diagnosis of renal tumours with clear cell histology. Pathology 42:374-383, 2010 - PubMed
Publication types
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous