The Constituents of the Stems of Cissus assamica and Their Bioactivities

Yu-Yi Chan¹, Chiu-Yuan Wang², Tsong-Long Hwang^{3

4

5}, Shin-Hun Juang⁶, Hsin-Yi Hung⁷, Ping-Chung Kuo⁸, Po-Jen Chen⁹, Tian-Shung Wu^{10

11}

Affiliations

¹ Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan. yuyichan@stust.edu.tw.
² Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan. m98h0104@gmail.com.
³ Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
⁴ Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
⁵ Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
⁶ Department of Pharmacy, Tajen University, Pingtung 90741, Taiwan. paul.juang@gmail.com.
⁷ School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. z10308005@email.ncku.edu.tw.
⁸ School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. z10502016@email.ncku.edu.tw.
⁹ Department of Cosmetic Science, Providence University, Taichung 433, Taiwan. litlep@hotmail.com.
¹⁰ Department of Pharmacy, Tajen University, Pingtung 90741, Taiwan. tswu@mail.ncku.edu.tw.
¹¹ School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. tswu@mail.ncku.edu.tw.

PMID: 30373325
PMCID: PMC6278371
DOI: 10.3390/molecules23112799

The Constituents of the Stems of Cissus assamica and Their Bioactivities

Yu-Yi Chan et al. Molecules. 2018.

. 2018 Oct 28;23(11):2799.

doi: 10.3390/molecules23112799.

Authors

Yu-Yi Chan¹, Chiu-Yuan Wang², Tsong-Long Hwang^{3

4

5}, Shin-Hun Juang⁶, Hsin-Yi Hung⁷, Ping-Chung Kuo⁸, Po-Jen Chen⁹, Tian-Shung Wu^{10

11}

Affiliations

¹ Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan. yuyichan@stust.edu.tw.
² Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan. m98h0104@gmail.com.
³ Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
⁴ Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
⁵ Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
⁶ Department of Pharmacy, Tajen University, Pingtung 90741, Taiwan. paul.juang@gmail.com.
⁷ School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. z10308005@email.ncku.edu.tw.
⁸ School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. z10502016@email.ncku.edu.tw.
⁹ Department of Cosmetic Science, Providence University, Taichung 433, Taiwan. litlep@hotmail.com.
¹⁰ Department of Pharmacy, Tajen University, Pingtung 90741, Taiwan. tswu@mail.ncku.edu.tw.
¹¹ School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. tswu@mail.ncku.edu.tw.

PMID: 30373325
PMCID: PMC6278371
DOI: 10.3390/molecules23112799

Abstract

Fifty-five compounds were isolated from the fresh stems of Cissus assamica, including 14 benzenoids, 11 triterpenes, nine steroids, five tocopherols, five chlorophylls, four flavonoids, two benzoquinones, two tannins, and three other compounds. Their structures were constructed by 1D and 2D nuclear magnetic resonance (NMR) and mass spectral data, and were also identified by a comparison of their spectral data with those reported in the literature. Among these isolates, 1,2-bis-(5--tocopheryl) ethane (51) was reported for the first time from natural sources. Some purified compounds were examined for their anti-inflammatory and anticancer bioactivities. The results indicated that betulinic acid (16) exhibited strong inhibition of superoxide anion generation with IC₅₀ value of 0.2 ± 0.1 μM, while betulinic acid (16) and pheophytin-a (47) inhibited elastase release with IC₅₀ value of 2.7 ± 0.3 and 5.3 ± 1.0 μM, respectively. In addition, betulinic acid (16) and epi-glut-5(6)-en-ol (18) exhibited potential cytotoxicity to non-small-cell lung carcinoma (NCI-H226) and colon cancer (HCT-116) cell lines with IC₅₀ values in the range of 1.6 to 9.1 μM.

Keywords: Vitaceae; anti-inflammatory; anticancer; cytotoxicity.

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Conflict of interest statement

References

Figures

**Figure 1**
Structures of compounds 16, 18, 47 and 51.

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The Constituents of the Stems of Cissus assamica and Their Bioactivities

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The Constituents of the Stems of Cissus assamica and Their Bioactivities

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