doi: 10.1128/mcb.7.5.1984-1988.1987.
Microinjection of ras p21 induces a rapid rise in intracellular pH
- PMID: 3037340
- PMCID: PMC365306
- DOI: 10.1128/mcb.7.5.1984-1988.1987
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Microinjection of ras p21 induces a rapid rise in intracellular pH
Mol Cell Biol.
1987 May.
Abstract
Quiescent mouse NIH 3T3 cells responded to microinjection of activated ras p21 with a rapid and sustained rise in intracellular pH (approximately 0.17 pH units). The p21-induced pH change was inhibited by amiloride treatment or growth of cells in medium low in sodium, suggesting a role for the Na+/H+ antiporter. Amiloride was found to suppress p21-induced mitosis, also.
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