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. 1987 May;7(5):1984-8.
doi: 10.1128/mcb.7.5.1984-1988.1987.

Microinjection of ras p21 induces a rapid rise in intracellular pH

N Hagag, J C Lacal, M Graber, S Aaronson, M V Viola

Microinjection of ras p21 induces a rapid rise in intracellular pH

N Hagag et al. Mol Cell Biol. 1987 May.

Abstract

Quiescent mouse NIH 3T3 cells responded to microinjection of activated ras p21 with a rapid and sustained rise in intracellular pH (approximately 0.17 pH units). The p21-induced pH change was inhibited by amiloride treatment or growth of cells in medium low in sodium, suggesting a role for the Na+/H+ antiporter. Amiloride was found to suppress p21-induced mitosis, also.

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References

    1. Nature. 1983 Aug 18-24;304(5927):645-8 - PubMed
    1. Nature. 1986 Sep 11-17;323(6084):173-6 - PubMed
    1. J Biol Chem. 1983 Oct 25;258(20):12644-53 - PubMed
    1. J Biol Chem. 1984 Apr 10;259(7):4313-9 - PubMed
    1. Biochem Biophys Res Commun. 1981 May 15;100(1):433-41 - PubMed

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