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. 1987 Jul;328(6127):215-20.
doi: 10.1038/328215a0.

The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors

G Grenningloh, A Rienitz, B Schmitt, C Methfessel, M Zensen, K Beyreuther, E D Gundelfinger, H Betz

The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors

G Grenningloh et al. Nature. 1987 Jul.

Abstract

We have cloned and sequenced cDNAs of the strychnine-binding subunit of the rat glycine receptor, a neurotransmitter-gated chloride channel protein of the CNS. The deduced polypeptide shows significant structural and amino-acid sequence homology with nicotinic acetylcholine receptor proteins, indicating that there is a family of genes encoding neurotransmitter-gated ion channels.

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