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. 1987 Jul;328(6127):221-7.
doi: 10.1038/328221a0.

Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family

P R Schofield, M G Darlison, N Fujita, D R Burt, F A Stephenson, H Rodriguez, L M Rhee, J Ramachandran, V Reale, T A Glencorse, et al.

Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family

P R Schofield et al. Nature. 1987 Jul.

Abstract

Amino-acid sequences derived from complementary DNAs encoding the alpha- and beta-subunits of the GABA/benzodiazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-channel-containing receptors. Co-expression of the in vitro-generated alpha-subunit and beta-subunit RNAs in Xenopus oocytes produces a functional receptor and ion channel with the pharmacological properties characteristic of the GABAA receptor.

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