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. 2018 Dec;66(12):2314-2320.
doi: 10.1111/jgs.15613. Epub 2018 Oct 30.

Association Between Sarcopenic Obesity and Falls in a Multiethnic Cohort of Postmenopausal Women

Shawna Follis  1 , Alan Cook  2 , Jennifer W Bea  3   4 , Scott B Going  4 , Deepika Laddu  5 , Jane A Cauley  6 , Aladdin H Shadyab  7 , Marcia L Stefanick  8 , Zhao Chen  1
Affiliations

Association Between Sarcopenic Obesity and Falls in a Multiethnic Cohort of Postmenopausal Women

Shawna Follis et al. J Am Geriatr Soc. 2018 Dec.

Abstract

Objectives: To investigate associations between sarcopenia, obesity, and sarcopenic obesity and incidence of falls in a racially and ethnically diverse cohort of healthy postmenopausal women.

Design: Prospective cohort study.

Setting: Three Women's Health Initiative (WHI) clinical centers (Tucson-Phoenix, AZ; Pittsburgh, PA; Birmingham, AL).

Participants: Postmenopausal women aged 50 to 79 enrolled in the WHI who underwent bone and body composition scans using dual-energy x-ray absorptiometry at baseline (N = 11,020).

Measurements: Sarcopenia was defined as the lowest 20th percentile of appendicular lean mass, correcting for height and body fat. Obesity was defined as a body fat percentage greater than 42%. Sarcopenic obesity was defined as co-occurrence of sarcopenia and obesity. The fall outcome was defined as falling 2 or more times in any year during 7 years of follow-up. The risk of falls associated with sarcopenic obesity were analyzed using log binomial regression models stratified according to age and race/ethnicity.

Results: Sarcopenic obesity was associated with greater risk of falls in women aged 50 to 64 (relative risk (RR) = 1.35, 95% confidence interval (CI)=1.17-1.56) and 65 to 79 (RR = 1.21, 95% CI=1.05-1.39). Sarcopenic obesity related fall risk was higher in Hispanic women (RR = 2.40, 95% CI=1.56-3.67) than non-Hispanic white women (RR = 1.24, 95% CI=1.11-1.39).

Conclusion: In a multiethnic cohort of postmenopausal women, sarcopenic obesity-related fall risk was high in women younger than 65 and those age 65 and older. Sarcopenic obesity posed the highest risk for falls in Hispanic women. The findings support identification of causal factors and health disparities in sarcopenic obesity to customize fall prevention strategies and ameliorate this significant public health burden. J Am Geriatr Soc 66:2314-2320, 2018.

Keywords: Women's Health Initiative; falls; obesity; race; sarcopenia.

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Figures

Figure 1.
Figure 1.
Participants included in the study
Figure 2:
Figure 2:
Sarcopenic obesity prevalence by race/ethnicity
See this image and copyright information in PMC

Comment in

  • Effects of Hormone Replacement Therapy on Sarcopenia: Is It Real?
    Ünsal P, Ayçiçek GŞ, Şendur A, Deniz O, Koca M, Boğa İ, Bürkük S, Cankurtaran M, Yavuz BB, Halil M. Ünsal P, et al. J Am Geriatr Soc. 2019 Jun;67(6):1297. doi: 10.1111/jgs.15807. Epub 2019 Jan 30. J Am Geriatr Soc. 2019. PMID: 30697703 No abstract available.

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