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Case Reports
. 2019;28(2):196-198.
doi: 10.1159/000494974. Epub 2018 Oct 30.

Pregnancy-Induced Sweet's Syndrome Treated with Infliximab

Brigita D Smolovic  1 , Mirjana D Gajic-Veljic  2 , Milos M Nikolic  2 , Damir F Muhovic  3
Affiliations
Case Reports

Pregnancy-Induced Sweet's Syndrome Treated with Infliximab

Brigita D Smolovic et al. Med Princ Pract. 2019.

Abstract

Objective: To present a case of relapsing and resistant Sweet's syndrome that developed during pregnancy together with an onset of Crohn's disease, showing complete resolution with the use of infliximab.

Clinical presentation and intervention: A 30-year-old pregnant woman presented with fever, skin lesions, and diarrhea. Skin biopsy confirmed neutrophilic dermatosis and she was diagnosed with Crohn's disease after endoscopy. There was no recurrence of Sweet's syndrome outside of her pregnancy. During a previous pregnancy, while corticosteroids were ineffective, complete regression of skin lesions was achieved using infliximab.

Conclusion: The "off-label" use of infliximab is beneficial for relapsing and resistant Sweet's syndrome.

Keywords: Crohn’s disease; Infliximab; Pregnancy; Sweet’s syndrome.

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Figures

Fig. 1
Fig. 1
Skin biopsy showed edema of the papillary dermis, a diffuse inflammatory infiltrate dominated by polymorphonuclear leukocytes, and necrosis of the reticular dermis (hematoxylin and eosin stain, ×100).
Fig. 2
Fig. 2
Skin lesion. a Skin lesion before infliximab. b Disappearance of skin lesion after infliximab.
See this image and copyright information in PMC

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