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Comment
. 2018 Dec;8(12):1500-1501.
doi: 10.1158/2159-8290.CD-NB2018-143. Epub 2018 Oct 30.

Combining Biomarkers for Immunotherapy

No authors listed
Comment

Combining Biomarkers for Immunotherapy

No authors listed. Cancer Discov. 2018 Dec.

Abstract

A biomarker analysis involving the largest dataset of its kind finds that tumor mutational burden and T cell-inflamed gene expression profile can independently predict a patient's response to pembrolizumab. However, joint consideration of both biomarkers offers the greatest clinical utility and identifies patterns of underlying, targetable biology.

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  • Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy.
    Cristescu R, Mogg R, Ayers M, Albright A, Murphy E, Yearley J, Sher X, Liu XQ, Lu H, Nebozhyn M, Zhang C, Lunceford JK, Joe A, Cheng J, Webber AL, Ibrahim N, Plimack ER, Ott PA, Seiwert TY, Ribas A, McClanahan TK, Tomassini JE, Loboda A, Kaufman D. Cristescu R, et al. Science. 2018 Oct 12;362(6411):eaar3593. doi: 10.1126/science.aar3593. Science. 2018. PMID: 30309915 Free PMC article.

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