Cooccurring JAK2 V617F and R1063H mutations increase JAK2 signaling and neutrophilia in myeloproliferative neoplasms

Cristina Mambet^{1

2

3}, Olga Babosova⁴, Jean-Philippe Defour^{2

5}, Emilie Leroy^{1

2}, Laura Necula³, Oana Stanca^{6

7}, Aurelia Tatic^{7

8}, Nicoleta Berbec^{6

7}, Daniel Coriu^{7

8}, Monika Belickova⁹, Barbora Kralova¹⁰, Lucie Lanikova⁴, Jitka Vesela⁹, Christian Pecquet^{1

2}, Pascale Saussoy⁵, Violaine Havelange¹¹, Carmen C Diaconu³, Vladimir Divoky¹⁰, Stefan N Constantinescu^{1

2

3}

Affiliations

¹ Ludwig Institute for Cancer Research, Brussels Branch, Brussels, Belgium.
² de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.
³ Molecular Profiling of Myeloproliferative Neoplasms and Acute Leukemia (MyeloAL) Program, Stefan S. Nicolau Institute of Virology, Bucharest, Romania.
⁴ Department of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
⁵ Department of Clinical Biology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
⁶ Department of Hematology, Coltea Clinical Hospital, Bucharest, Romania.
⁷ Department of Radiology, Oncology, and Hematology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
⁸ Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania.
⁹ Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
¹⁰ Department of Biology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; and.
¹¹ Service of Hematology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

Free article

Cristina Mambet et al. Blood. 2018.

Free article

. 2018 Dec 20;132(25):2695-2699.

doi: 10.1182/blood-2018-04-843060. Epub 2018 Oct 30.

¹ Ludwig Institute for Cancer Research, Brussels Branch, Brussels, Belgium.
² de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.
³ Molecular Profiling of Myeloproliferative Neoplasms and Acute Leukemia (MyeloAL) Program, Stefan S. Nicolau Institute of Virology, Bucharest, Romania.
⁴ Department of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
⁵ Department of Clinical Biology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
⁶ Department of Hematology, Coltea Clinical Hospital, Bucharest, Romania.
⁷ Department of Radiology, Oncology, and Hematology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
⁸ Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania.
⁹ Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
¹⁰ Department of Biology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; and.
¹¹ Service of Hematology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

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