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Comment
. 2019 Jan 1;25(1):9-11.
doi: 10.1158/1078-0432.CCR-18-2819. Epub 2018 Oct 30.

Right Time and Place for IL12: Targeted Delivery Stimulates Immune Therapy

H Kim Lyerly  1   2   3 , Takuya Osada  4 , Zachary C Hartman  4   2
Affiliations
Comment

Right Time and Place for IL12: Targeted Delivery Stimulates Immune Therapy

H Kim Lyerly et al. Clin Cancer Res. .

Abstract

Systemic IL12 therapy has potent antitumor effects, but clinical delivery of this potent cytokine has been complicated by systemic toxicity. A novel strategy to deliver IL12 to the tumor microenvironment appears promising in a first-in-human study, appearing to stimulate tumor-specific adaptive immune responses with minimal systemic toxicity.See related article by Strauss et al., p. 99.

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