Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2018 Nov 23;38(6):BSR20181235.
doi: 10.1042/BSR20181235. Print 2018 Dec 21.

TIM-3 rs1036199 polymorphism increases susceptibility to autoimmune diseases: evidence based on 4200 subjects

Rongzeng Liu  1 , Xing Wang  2 , Xiafei Chen  3 , Shengnan Wang  2 , Heqian Zhang  2
Affiliations
Meta-Analysis

TIM-3 rs1036199 polymorphism increases susceptibility to autoimmune diseases: evidence based on 4200 subjects

Rongzeng Liu et al. Biosci Rep. .

Abstract

Conflicting results have been reported regarding differing studies on the association between T-cell immunoglobulin and mucin domain 3 polymorphisms and autoimmune disease. The purpose of the present study was to evaluate the association of TIM-3 rs1036199 (4259 G/T) polymorphism with autoimmune disease susceptibility. A meta-analysis was performed to obtain a more precise evaluation of the association. Ten eligible studies were retrieved by searching PubMed, Embase and Web of Science databases, and statistical analyses were performed using STATA software. The pooled results indicated that TIM-3 rs1036199 polymorphism was significantly associated with an increased risk of overall autoimmune disease in allele comparison (G versus T: OR = 1.59, 95%CI: 1.17-2.17) and heterozygous comparison (GT versus TT: OR = 1.68, 95%CI: 1.37-2.06). Subgroup analyses based on disease type demonstrated that TIM-3 rs1036199 polymorphism was associated with an increased risk of rheumatic arthritis (G versus T: OR = 1.88, 95%CI: 1.45-2.44; GT versus TT: OR = 2.02, 95%CI: 1.53-2.65), especially in Asian populations.

Keywords: Autoimmune diseases; Meta-analysis; Polymorphism; TIM-3.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no competing interests associated with the manuscript.

Figures

Figure 1
Figure 1. Process of study selection in this meta-analysis
Figure 2
Figure 2. Forest plot of OR with 95% CI for TIM-3 rs1036199 polymorphism and AD risk in allele model (G vs T)
(A) Overall results; (B) stratified analysis by ethnicity; (C) subgroup analysis by design of study; (D) stratified analysis by AD types.
Figure 3
Figure 3. Forest plot of OR with 95% CI for TIM-3 rs1036199 polymorphism and AD risk in heterozygote model (GT vs TT)
(A) Overall results; (B) stratified analysis by ethnicity; (C) subgroup analysis by design of study; (D) stratified analysis by AD types.
Figure 4
Figure 4. Sensitivity analysis of association between TIM-3 rs1036199 polymorphism and AD risk. (A) allele model; (B) heterozygote model.
Figure 5
Figure 5. Begg’s funnel plot evaluating evidence of publication bias from the eligible studies. (A) allele model; (B) heterozygote model.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Marson A., Housley W.J. and Hafler D.A. (2015) Genetic basis of autoimmunity. J. Clin. Invest. 125, 2234–2241 10.1172/JCI78086 - DOI - PMC - PubMed
    1. Vyse T.J. and Todd J.A. (1996) Genetic analysis of autoimmune disease. Cell 85, 311–318 10.1016/S0092-8674(00)81110-1 - DOI - PubMed
    1. Zhernakova A., Withoff S. and Wijmenga C. (2013) Clinical implications of shared genetics and pathogenesis in autoimmune diseases. Nat. Rev. Endocrinol. 9, 646–659 10.1038/nrendo.2013.161 - DOI - PubMed
    1. Richard-Miceli C. and Criswell L.A. (2012) Emerging patterns of genetic overlap across autoimmune disorders. Genome Med. 4, 6 10.1186/gm305 - DOI - PMC - PubMed
    1. Zhernakova A., van Diemen C.C. and Wijmenga C. (2009) Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nat. Rev. Genet. 10, 43–55 10.1038/nrg2489 - DOI - PubMed

Publication types

Substances