Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Nov 13;115(46):E10810-E10811.
doi: 10.1073/pnas.1813967115. Epub 2018 Oct 30.

Reply to Oegema et al.: CFI-400945 and Polo-like kinase 4 inhibition

Masanori Kawakami  1 , Lisa Maria Mustachio  1 , Lin Zheng  1 , Yulong Chen  1 , Jaime Rodriguez-Canales  2 , Barbara Mino  2 , Jonathan M Kurie  1 , Jason Roszik  3   4 , Pamela Andrea Villalobos  2 , Kelsie L Thu  5 , Jennifer Silvester  5 , David W Cescon  5   6 , Ignacio I Wistuba  2 , Tak W Mak  7   8 , Xi Liu  1 , Ethan Dmitrovsky  1   9   10
Affiliations
Comment

Reply to Oegema et al.: CFI-400945 and Polo-like kinase 4 inhibition

Masanori Kawakami et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of interest statement: K.L.T., J.S., D.W.C., and T.W.M. declare that CFI-400945 is owned and being developed by the University Health Network. The remaining authors declare no conflict of interest.

Comment on

  • Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers.
    Kawakami M, Mustachio LM, Zheng L, Chen Y, Rodriguez-Canales J, Mino B, Kurie JM, Roszik J, Villalobos PA, Thu KL, Silvester J, Cescon DW, Wistuba II, Mak TW, Liu X, Dmitrovsky E. Kawakami M, et al. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1913-1918. doi: 10.1073/pnas.1719760115. Epub 2018 Feb 6. Proc Natl Acad Sci U S A. 2018. PMID: 29434041 Free PMC article.
  • CFI-400945 is not a selective cellular PLK4 inhibitor.
    Oegema K, Davis RL, Lara-Gonzalez P, Desai A, Shiau AK. Oegema K, et al. Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10808-E10809. doi: 10.1073/pnas.1813310115. Epub 2018 Oct 30. Proc Natl Acad Sci U S A. 2018. PMID: 30377272 Free PMC article. No abstract available.

References

    1. Oegema K, Davis RL, Lara-Gonzalez P, Desai A, Shiau AK. CFI-400945 is not a selective cellular PLK4 inhibitor. Proc Natl Acad Sci USA. 2018;115:E10808–E10809. - PMC - PubMed
    1. Kawakami M, et al. Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers. Proc Natl Acad Sci USA. 2018;115:1913–1918. - PMC - PubMed
    1. Wong YL, et al. Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science. 2015;348:1155–1160. - PMC - PubMed
    1. Mason JM, et al. Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent. Cancer Cell. 2014;26:163–176. - PubMed
    1. Sampson PB, et al. The discovery of Polo-like kinase 4 inhibitors: Identification of (1R,2S)-2-(3-((E)-4-(((cis)-2,6-dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a potent, orally active antitumor agent. J Med Chem. 2015;58:147–169. - PubMed

Substances

LinkOut - more resources