Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Aug 20;9(3):16-24.
doi: 10.5365/wpsar.2018.9.1.008. eCollection 2018 Jul-Sep.

Viral load suppression and acquired HIV drug resistance in adults receiving antiretroviral therapy in Viet Nam: results from a nationally representative survey

Vu Quoc Dat  1 , Bui Duc Duong  2 , Do Thi Nhan  2 , Nguyen Huu Hai  2 , Nguyen Thi Lan Anh  3 , Huynh Hoang Khanh Thu  4 , Tran Ton  4 , Luong Que Anh  4 , Nguyen Tuan Nghia  3 , Nguyen Vu Thuong  4 , Khuu Van Nghia  4 , Tran Thi Minh Tam  3 , Tran Phuc Hau  4 , Nguyen Duy Phuc  4 , Vu Xuan Thinh  4 , Nguyen Tran Hien  3 , Truong Thi Xuan Lien  4 , Silvia Bertagnolio  5 , Nguyen Thi Thuy Van  6 , Masaya Kato  6
Affiliations

Viral load suppression and acquired HIV drug resistance in adults receiving antiretroviral therapy in Viet Nam: results from a nationally representative survey

Vu Quoc Dat et al. Western Pac Surveill Response J. .

Abstract

Objective: The purpose of this survey was to estimate the prevalence of viral load (VL) suppression and emergence of HIV drug resistance (HIVDR) among individuals receiving antiretroviral therapy (ART) for 36 months or longer in Viet Nam using a nationally representative sampling method.

Methods: The survey was conducted between May and August 2014 using a two-stage cluster design. Sixteen ART clinics were selected using probability proportional to proxy size sampling, and patients receiving ART for at least 36 months were consecutively enrolled. Epidemiological information and blood specimens were collected for HIV-1 VL and HIVDR testing; HIVDR was defined by the Stanford University HIVDR algorithm.

Results: Overall, 365 eligible individuals were recruited with a mean age of 38.2 years; 68.4% were men. The mean time on ART was 75.5 months (95% confidence interval [CI]: 69.0-81.9 months), and 93.7% of the patients were receiving non-nucleoside reverse transcriptase inhibitor-based regimens. Of the 365 individuals, 345 (94.7%, 95% CI: 64.1-99.4%) had VL below 1000 copies/mL and 19 (4.6%, 95% CI: 2.8--7.5) had HIVDR mutations.

Discussion: Our nationally representative survey found a high level of VL suppression and a low prevalence of HIVDR among individuals who received ART for at least 36 months in Viet Nam. Continued surveillance for HIVDR is important for evaluating and improving HIV programs.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Frequency of mutations conferring resistance to NRTIs
See this image and copyright information in PMC

References

    1. Know your epidemic. Hanoi: The Joint United Nations Programme on HIV/AIDS (UNAIDS) Viet Nam; 2017 (http://unaids.org.vn/en/know-your-epidemic/, accessed 19 November 2017).
    1. VAAC. Global AIDS Monitoring 2017 - Report from Viet Nam. Hanoi: Viet Nam Authority of HIV/AIDS Control; 2017.
    1. Reporting on HIV/AIDS prevention in 2015 and important mission in 2016. Hanoi: Viet Nam Ministry of Health; 2016 (http://vaac.gov.vn/Cms_Data/Contents/Vaac/Folders/Solieubaocao/Solieu/~c...) (in Vietnamese).
    1. Jordan MR, Bennett DE, Bertagnolio S, Gilks CF, Sutherland D. World Health Organization surveys to monitor HIV drug resistance prevention and associated factors in sentinel antiretroviral treatment sites. Antivir Ther. 2008;13 Suppl 2:15–23. - PubMed
    1. WHO. Surveillance of HIV drug resistance in adults receiving ART (acquired HIV drug resistance). Geneva: World Health Organization; 2014.

Substances

LinkOut - more resources