Adaptive designs in clinical trials in critically ill patients: principles, advantages and pitfalls

C H van Werkhoven¹, S Harbarth^{2

3}, M J M Bonten^{4

5}

Affiliations

¹ Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. c.h.vanwerkhoven@umcutrecht.nl.
² Infection Control Program and WHO Collaborating Center, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
³ Division of Infectious Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
⁴ Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
⁵ Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.

C H van Werkhoven et al. Intensive Care Med. 2019 May.

. 2019 May;45(5):678-682.

doi: 10.1007/s00134-018-5426-z. Epub 2018 Oct 30.

C H van Werkhoven¹, S Harbarth^{2

3}, M J M Bonten^{4

5}

¹ Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. c.h.vanwerkhoven@umcutrecht.nl.
² Infection Control Program and WHO Collaborating Center, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
³ Division of Infectious Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
⁴ Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
⁵ Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.

No abstract available

Conflict of interest statement

The authors declare that they have no conflict of interest related to the topic of this paper.

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