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. 2018 Dec;9(6):2393-2398.
doi: 10.1007/s13300-018-0527-9. Epub 2018 Oct 30.

Concentrations of VEGF and PlGF Decrease in Eyes After Intravitreal Conbercept Injection

Jun Zhou  1   2 , Zheng Liu  1   3 , Meng Chen  1 , Zhi-Heng Luo  4 , Yun-Qiu Li  3 , Guang-Ying Qi  3 , Tao Liu  5
Affiliations

Concentrations of VEGF and PlGF Decrease in Eyes After Intravitreal Conbercept Injection

Jun Zhou et al. Diabetes Ther. 2018 Dec.

Abstract

Introduction: Conbercept is a new anti-vascular endothelial growth factor drug approved for the treatment of age-related macular degeneration by the China Food and Drug Administration (CFDA) in 2013. In this study, we for the first time evaluated the concentrations of vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) after patients with proliferative diabetic retinopathy were treated with intravitreal conbercept (IVC) injection.

Methods: Sixteen patients with proliferative diabetic retinopathy were randomly divided into two equal groups (A and B). Nine patients with rhegmatogenous retinal detachment were used as the control group. The patients in group A received 0.5 mg IVC and their aqueous humor was collected. After 7 days, all patients underwent vitrectomy, and their aqueous and vitreous humor were collected.

Results: In the aqueous humor, the concentrations of VEGF and PlGF were higher pre- than post-IVC injection in group A. Similarly, the concentrations of VEGF and PlGF in group A (pre-IVC) and group B were higher than those in the control group. In vitreous humor, the concentrations of VEGF and PlGF were higher in group B than those in the control group, and the concentrations of VEGF were lower in group A (post-IVC) than those in group B.

Conclusions: Our study proved that the concentration of VEGF and PlGF reduced after IVC injection in aqueous humor. However, the concentration of PlGF did not reduce after IVC injection in vitreous humor.

Keywords: Aqueous humor; Conbercept; Placental growth factor; Vascular endothelial growth factor; Vitreous humor.

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Figures

Fig. 1
Fig. 1
Before and after the patients received the intravitreal conbercept treatment and underwent vitrectomy. a Schematic flow diagram of the process in this work. b Concentrations of VEGF and PlGF in the aqueous and vitreous humor pre- and post-intravitreal conbercept injection. c Correlation between the concentrations of VEGF and PlGF in the aqueous and vitreous humor. **p < 0.01
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