Invasive Neuromodulation for the Treatment of Pediatric Epilepsy

Laureen D Hachem¹, Han Yan¹, George M Ibrahim²

Affiliations

¹ Division of Neurosurgery, Hospital for Sick Children, Department of Surgery, University of Toronto, 1503 555 University Ave., Toronto, ON, M5G 1X8, Canada.
² Division of Neurosurgery, Hospital for Sick Children, Department of Surgery, University of Toronto, 1503 555 University Ave., Toronto, ON, M5G 1X8, Canada. george.ibrahim@sickkids.ca.

PMID: 30378003
PMCID: PMC6361060
DOI: 10.1007/s13311-018-00685-1

Review

Invasive Neuromodulation for the Treatment of Pediatric Epilepsy

Laureen D Hachem et al. Neurotherapeutics. 2019 Jan.

. 2019 Jan;16(1):128-133.

doi: 10.1007/s13311-018-00685-1.

Authors

Laureen D Hachem¹, Han Yan¹, George M Ibrahim²

Affiliations

¹ Division of Neurosurgery, Hospital for Sick Children, Department of Surgery, University of Toronto, 1503 555 University Ave., Toronto, ON, M5G 1X8, Canada.
² Division of Neurosurgery, Hospital for Sick Children, Department of Surgery, University of Toronto, 1503 555 University Ave., Toronto, ON, M5G 1X8, Canada. george.ibrahim@sickkids.ca.

PMID: 30378003
PMCID: PMC6361060
DOI: 10.1007/s13311-018-00685-1

Abstract

Neuromodulatory strategies are increasingly adopted for the treatment of intractable epilepsy in children. These encompass a wide range of treatments aimed at externally stimulating neural circuitry in order to decrease seizure frequency. In the current review, the authors discuss the evidence for invasive neuromodulation, namely vagus nerve and deep brain stimulation in affected children. Putative mechanisms of action and biomarkers of treatment success are explored and evidence of the efficacy of invasive neuromodulation is highlighted.

Keywords: Biomarkers; deep brain stimulation; epilepsy; seizures; vagus nerve stimulation.

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Invasive Neuromodulation for the Treatment of Pediatric Epilepsy

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Invasive Neuromodulation for the Treatment of Pediatric Epilepsy

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