Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1987 Apr;31(4):614-6.
doi: 10.1128/AAC.31.4.614.

Monocyclic and tricyclic analogs of quinolones: mechanism of action

N H Georgopapadakou, B A Dix, P Angehrn, A Wick, G L Olson
Comparative Study

Monocyclic and tricyclic analogs of quinolones: mechanism of action

N H Georgopapadakou et al. Antimicrob Agents Chemother. 1987 Apr.

Abstract

The mode of action of Ro 13-5478 and Ro 14-9578, monocyclic and tricyclic quinolone analogs, respectively, was examined for Escherichia coli and Staphylococcus aureus. The compounds showed antibacterial activity and effects on cell morphology, replicative DNA biosynthesis, and gyrase-catalyzed DNA supercoiling that were comparable to those shown by nalidixic acid and by oxolinic acid compounds. The results suggest that their site of action is DNA gyrase and that a bicyclic quinolone nucleus is not essential for activity.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Proc Natl Acad Sci U S A. 1970 Oct;67(2):674-81 - PubMed
    1. J Bacteriol. 1965 Apr;89:1068-74 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 Jun;72(6):2330-4 - PubMed
    1. Eur J Biochem. 1976 Mar 1;62(3):491-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1976 Nov;73(11):3872-6 - PubMed

Publication types

MeSH terms

LinkOut - more resources