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Comparative Study
. 1987 Apr;31(4):614-6.
doi: 10.1128/AAC.31.4.614.

Monocyclic and tricyclic analogs of quinolones: mechanism of action

N H Georgopapadakou, B A Dix, P Angehrn, A Wick, G L Olson
Comparative Study

Monocyclic and tricyclic analogs of quinolones: mechanism of action

N H Georgopapadakou et al. Antimicrob Agents Chemother. 1987 Apr.

Abstract

The mode of action of Ro 13-5478 and Ro 14-9578, monocyclic and tricyclic quinolone analogs, respectively, was examined for Escherichia coli and Staphylococcus aureus. The compounds showed antibacterial activity and effects on cell morphology, replicative DNA biosynthesis, and gyrase-catalyzed DNA supercoiling that were comparable to those shown by nalidixic acid and by oxolinic acid compounds. The results suggest that their site of action is DNA gyrase and that a bicyclic quinolone nucleus is not essential for activity.

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