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Editorial
. 2019 Feb 1;115(2):261-263.
doi: 10.1093/cvr/cvy270.

Cyclophilin D phosphorylation is critical for mitochondrial calcium uniporter regulated permeability transition pore sensitivity

Rimpy Dhingra  1 , Brooke Lieberman  1 , Lorrie A Kirshenbaum  1   2
Affiliations
Editorial

Cyclophilin D phosphorylation is critical for mitochondrial calcium uniporter regulated permeability transition pore sensitivity

Rimpy Dhingra et al. Cardiovasc Res. .
No abstract available

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Figures

Figure 1
Figure 1
Phosphorylation of cyclophilin D at serine 42 triggers permeability transition pore opening. In the absence of MCU, CypD is phosphorylated at serine 42 and provokes mitochondrial perturbations and cell death. Left panel: Mitochondria with intact MCU, demonstrate regulated calcium (Ca2+) entry into mitochondrial matrix. Absence of CypD phosphorylation coincides with high CRC and mPTP closure. Right panel: In MCU-KO hearts, CypD is phosphorylated at serine 42, and this modification results in association between CypD and F0/F1ATPase. CypD S42 phosphorylation leads to reduced CRC of mitochondria, mPTP opening, and cell death.
See this image and copyright information in PMC

Comment on

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