Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Feb;76(4):681-697.
doi: 10.1007/s00018-018-2954-1. Epub 2018 Oct 31.

Comprehensive review on how platinum- and taxane-based chemotherapy of ovarian cancer affects biology of normal cells

Justyna Mikuła-Pietrasik  1 , Anna Witucka  1 , Martyna Pakuła  1 , Paweł Uruski  1 , Beata Begier-Krasińska  1 , Arkadiusz Niklas  1 , Andrzej Tykarski  1 , Krzysztof Książek  2
Affiliations
Review

Comprehensive review on how platinum- and taxane-based chemotherapy of ovarian cancer affects biology of normal cells

Justyna Mikuła-Pietrasik et al. Cell Mol Life Sci. 2019 Feb.

Abstract

One of the most neglected aspects of chemotherapy are changes, and possible consequences of these changes, that occur in normal somatic cells. In this review, we summarize effects of selected drugs used to treat ovarian cancer (platin derivatives-cisplatin and carboplatin; and taxanes-paclitaxel and docetaxel) on cellular metabolism, acquisition of reactive stroma features, cellular senescence, inflammatory reactions, apoptosis, autophagy, mitophagy, oxidative stress, DNA damage, and angiogenesis in various types of normal cells, including fibroblasts, epithelial cells, endothelial cells, and neurons. The activity of these drugs against the normal cells is presented from a broader perspective of their desirable anti-tumoral effects.

Keywords: Chemotherapy; Ovarian cancer; Platin analogs; Side effects; Taxanes.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Mechanisms of cisplatin and carboplatin cytotoxicity in cancer cells
Fig. 2
Fig. 2
Mechanisms of paclitaxel and docetaxel cytotoxicity in cancer cells
See this image and copyright information in PMC

References

    1. Kayl AE, Meyers CA. Side-effects of chemotherapy and quality of life in ovarian and breast cancer patients. Curr Opin Obstet Gynecol. 2006;18(1):24–28. doi: 10.1097/01.gco.0000192996.20040.24. - DOI - PubMed
    1. Murias M, Luczak MW, Niepsuj A, Krajka-Kuzniak V, Zielinska-Przyjemska M, Jagodzinski PP, Jager W, Szekeres T, Jodynis-Liebert J. Cytotoxic activity of 3,3′,4,4′,5,5′-hexahydroxystilbene against breast cancer cells is mediated by induction of p53 and downregulation of mitochondrial superoxide dismutase. Toxicol In Vitro. 2008;22(5):1361–1370. doi: 10.1016/j.tiv.2008.03.002. - DOI - PubMed
    1. Mikula-Pietrasik J, Sosinska P, Wierzchowski M, Piwocka K, Ksiazek K. Synthetic resveratrol analogue, 3,3′,4,4′,5,5′-hexahydroxy-trans-stilbene, accelerates senescence in peritoneal mesothelium and promotes senescence-dependent growth of gastrointestinal cancers. Int J Mol Sci. 2013;14(11):22483–22498. doi: 10.3390/ijms141122483. - DOI - PMC - PubMed
    1. Raja FA, Chopra N, Ledermann JA. Optimal first-line treatment in ovarian cancer. Ann Oncol. 2012;23(Suppl 10):x118–x127. doi: 10.1093/annonc/mds315. - DOI - PubMed
    1. Jelovac D, Armstrong DK. Recent progress in the diagnosis and treatment of ovarian cancer. CA Cancer J Clin. 2011;61(3):183–203. doi: 10.3322/caac.20113. - DOI - PMC - PubMed

MeSH terms