Immune Aberrations in Obsessive-Compulsive Disorder: a Systematic Review and Meta-analysis

Theodore D Cosco^{1

2}, Toby Pillinger³, Hadeer Emam⁴, Marco Solmi^{5

6}, Sanjay Budhdeo^{7

8}, A Matthew Prina⁹, Michael Maes^{10

11}, Dan J Stein¹², Brendon Stubbs^#^{13

14

15}, Andre F Carvalho^#^{16

17

18}

Affiliations

¹ Gerontology Research Center, Simon Fraser University, Vancouver, Canada.
² Oxford Institute of Population Ageing, University of Oxford, Oxford, UK.
³ Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, UK.
⁴ Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT, USA.
⁵ Neurosciences Department, University of Padua, Padua, Italy.
⁶ Padova Neuroscience Center, University of Padua, Padua, Italy.
⁷ National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
⁸ Institute of Neurology, University College London, London, UK.
⁹ Health Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, UK.
¹⁰ Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
¹¹ IMPACT Strategic Research Center, Deakin University, Geelong, Australia.
¹² Department of Psychiatry and MRC Unit on Risk and Resilience in Mental Disorders, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.
¹³ Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, London, UK.
¹⁴ Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, UK.
¹⁵ Faculty of Health, Social Care and Education, Anglia Ruskin University, Chelmsford, UK.
¹⁶ Department of Psychiatry, University of Toronto, Toronto, ON, Canada. andrefc7@hotmail.com.
¹⁷ Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada. andrefc7@hotmail.com.
¹⁸ Faculty of Medicine, University of Toronto, Toronto, ON, Canada. andrefc7@hotmail.com.

^# Contributed equally.

PMID: 30382535
DOI: 10.1007/s12035-018-1409-x

Meta-Analysis

Immune Aberrations in Obsessive-Compulsive Disorder: a Systematic Review and Meta-analysis

Theodore D Cosco et al. Mol Neurobiol. 2019 Jul.

. 2019 Jul;56(7):4751-4759.

doi: 10.1007/s12035-018-1409-x. Epub 2018 Oct 31.

Authors

Affiliations

¹ Gerontology Research Center, Simon Fraser University, Vancouver, Canada.
² Oxford Institute of Population Ageing, University of Oxford, Oxford, UK.
³ Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, UK.
⁴ Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT, USA.
⁵ Neurosciences Department, University of Padua, Padua, Italy.
⁶ Padova Neuroscience Center, University of Padua, Padua, Italy.
⁷ National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
⁸ Institute of Neurology, University College London, London, UK.
⁹ Health Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, UK.
¹⁰ Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
¹¹ IMPACT Strategic Research Center, Deakin University, Geelong, Australia.
¹² Department of Psychiatry and MRC Unit on Risk and Resilience in Mental Disorders, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.
¹³ Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, London, UK.
¹⁴ Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, UK.
¹⁵ Faculty of Health, Social Care and Education, Anglia Ruskin University, Chelmsford, UK.
¹⁶ Department of Psychiatry, University of Toronto, Toronto, ON, Canada. andrefc7@hotmail.com.
¹⁷ Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada. andrefc7@hotmail.com.
¹⁸ Faculty of Medicine, University of Toronto, Toronto, ON, Canada. andrefc7@hotmail.com.

^# Contributed equally.

PMID: 30382535
DOI: 10.1007/s12035-018-1409-x

Abstract

Some lines of evidence have indicated that immune dysregulation could play a role in the pathophysiology of obsessive-compulsive disorder (OCD). However, results have been inconsistent across studies. Thus, a systematic review and meta-analysis of studies measuring immune mediators in participants with OCD compared to healthy controls (HC) was conducted. The PubMed/MEDLINE, PsycINFO, and EMBASE electronic databases were systematically searched from inception through June 21, 2018. Sixteen studies met inclusion criteria comprising data from 1001 participants (538 with OCD and 463 were HCs). Levels of TNF-α, IL-6, IL-1β, IL-4, IL-10, and interferon-γ did not significantly differ between participants with OCD and healthy controls. In addition, the ex vivo production of TNF-α and IL-6 by isolated macrophages did not significantly differ between participants with OCD and HCs. Nevertheless, included studies have varied in methodological quality with the enrollment of samples that differed regarding medication status, the proper matching of OCD participants and HCs, age groups, and the presence of psychiatric comorbidities. In conclusion, an association between immune dysregulation and OCD remains unproven. Future studies should consider enrolling larger and more homogeneous samples with OCD.

Keywords: Chemokines; Cytokines; Inflammation; Meta-analysis; Obsessive-compulsive disorder; Review.

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References

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Immune Aberrations in Obsessive-Compulsive Disorder: a Systematic Review and Meta-analysis

Affiliations

Immune Aberrations in Obsessive-Compulsive Disorder: a Systematic Review and Meta-analysis

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous