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. 2018 Nov 1;13(11):e0206893.
doi: 10.1371/journal.pone.0206893. eCollection 2018.

Age-based health and economic burden of skin and soft tissue infections in the United States, 2000 and 2012

Khine Tun  1   2 , James F Shurko  1   2 , Laurajo Ryan  1   2 , Grace C Lee  1   2
Affiliations

Age-based health and economic burden of skin and soft tissue infections in the United States, 2000 and 2012

Khine Tun et al. PLoS One. .

Abstract

Objective: The aim of this study was to compare the incidence of skin and soft tissue infections (SSTIs) across healthcare settings and analyze direct healthcare expenditures related to SSTIs in 2000 and 2012 in the United States.

Methods: We performed a retrospective, cross-sectional analysis of nationally representative data from the Medical Expenditure Panel Surveys. Population-based incidence rates were examined for all healthcare settings that include inpatient visits, emergency department visits and ambulatory visits for SSTIs. The direct costs of healthcare services utilization were reported. Population-based prescribing rates for each antimicrobial class during ambulatory visits were compared.

Results: A total of 2.4 million patients experienced an SSTI in 2000 compared to 3.3 million in 2012 (40% increase). From 2000 to 2012, the incidence of patients with at least one hospital visit for SSTIs increased 22%, ambulatory care visits increased 30%, and emergency department visits increased 40%. The incidence of SSTIs in children and adolescents declined 50% (from 150 to 76 per 10,000 person; RR = 0.51, 95% CI: 0.38-0.67; p<0.001) whereas SSTIs in older adults (> 65 years of age) increased almost 2-fold (from 67 to 130 per 10,000 person; RR = 1.94, 95% CI: 1.44-2.61; p<0.001). The annual incidence of SSTI in adults did not change significantly from 2000 to 2012 (from 84 to 81 per 10,000 person; RR = 0.96, 95% CI: 0.71-1.31; p = 0.41). The total estimated direct healthcare costs of SSTIs increased 3-fold from $4.8 billion in 2000 to $15.0 billion in 2012, largely driven by an 8-fold increase in ambulatory expenditures for SSTIs. Total population-based antimicrobial prescription rates for SSTIs increased 4-fold from 2000 to 2012 (from 59.5 to 250.4 per 10,000 person).

Conclusions: The highest healthcare utilization for SSTI treatment occurred in the ambulatory care setting and also accounted for the largest increase in overall direct expenditures from 2000 to 2012.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Incidence of SSTIs by healthcare setting, 2000 and 2012.
Fig 2
Fig 2. Total U.S. direct expenditures for SSTIs by healthcare service, 2000 and 2012.
Fig 3
Fig 3. Most frequently prescribed antibiotics for SSTIs, 2000, 2007 and 2012.
TMP-SMX = sulfamethoxazole-trimethoprim.
See this image and copyright information in PMC

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