Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Feb;67(2):425-32.

Modification of beta-2-microglobulin in sera from patients with small cell lung cancer: evidence for involvement of a serine protease

M H Nissen, O J Bjerrum, T Plesner, M Wilken, M Rørth

Modification of beta-2-microglobulin in sera from patients with small cell lung cancer: evidence for involvement of a serine protease

M H Nissen et al. Clin Exp Immunol. 1987 Feb.

Abstract

Modification of beta-2-microglobulin has been shown to occur in vitro in serum of patients suffering of small cell lung cancer, where it clearly correlated to the clinical course of disease. The cause of serum beta-2-microglobulin modification occurring in these patients is investigated in the present study. This revealed that modification of beta-2-microglobulin is due to cleavage by a serine protease, which is dependent on divalent cations and has a trypsin-like specificity. The process showed the following characteristics: pH optimum at 8.5, heat inactivation by incubation at 56 degrees C for 20 min and temperature optimum at 20 degrees C.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Biochem J. 1978 Nov 1;175(2):383-90 - PubMed
    1. Clin Chim Acta. 1977 May 16;77(1):37-42 - PubMed
    1. Allergy. 1980 Dec;35(8):627-37 - PubMed
    1. Clin Chem. 1982 Oct;28(10):2033-9 - PubMed
    1. Clin Chim Acta. 1983 Oct 31;134(1-2):167-76 - PubMed

Publication types

LinkOut - more resources