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. 1987 Jun;6(6):1637-42.
doi: 10.1002/j.1460-2075.1987.tb02412.x.

The activation antigen BLAST-2, when shed, is an autocrine BCGF for normal and transformed B cells

S Swendeman, D A Thorley-Lawson

The activation antigen BLAST-2, when shed, is an autocrine BCGF for normal and transformed B cells

S Swendeman et al. EMBO J. 1987 Jun.

Abstract

A shed form of the membrane-bound B cell activation marker, BLAST-2 (Epstein-Barr virus cell surface, CD 23) was immune-affinity purified from Epstein-Barr virus-transformed lymphoblast conditioned medium. SDS-PAGE analysis revealed a complex of two polypeptides, mol. wts 25,000 and 12,000, here termed s-BLAST-2. We show that this complex, when purified to homogeneity, can act as a growth factor for EBV-infected B lymphoblasts and normal receptor-stimulated B cell blasts. It has no effect on resting B or T cells. These data suggest that the BLAST-2 antigen has a role in autocrine B cell growth. Additionally, this complex is a co-mitogen for PHA-stimulated murine thymocytes, a property of interleukin-1.

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References

    1. Cancer Res. 1978 Nov;38(11 Pt 2):4147-54 - PubMed
    1. Eur J Immunol. 1986 Sep;16(9):1075-80 - PubMed
    1. J Immunol. 1981 Mar;126(3):1075-9 - PubMed
    1. J Immunol. 1982 Sep;129(3):1104-8 - PubMed
    1. Cell. 1982 Sep;30(2):415-25 - PubMed

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