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. 1987 Jun;6(6):1741-6.
doi: 10.1002/j.1460-2075.1987.tb02426.x.

Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells

G Matlashewski, J Schneider, L Banks, N Jones, A Murray, L Crawford

Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells

G Matlashewski et al. EMBO J. 1987 Jun.

Abstract

The close association of human papillomavirus type 16 DNA with a majority of cervical carcinomas implies some role for the virus in this type of cancer. To define the transforming properties of HPV-16 DNA in vitro we have now performed transfection experiments on baby rat kidney cells using HPV-16 DNA in conjunction with an activated ras gene. We have demonstrated that a 6.6-kb DNA fragment, containing the early genes of HPV-16 under the control of Moloney murine leukaemia virus long terminal repeats (MoMuLV-LTRs), cooperates with EJ-ras in transforming these cells. Both DNAs are required and neither alone is effective. The cooperating activity appears to reside in a protein or proteins derived from the E6/E7 region of the HPV-16 genome.

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