Does Rheumatoid Arthritis Really Improve During Pregnancy? A Systematic Review and Metaanalysis

doi:10.3899/jrheum.180226

Meta-Analysis

. 2019 Mar;46(3):245-250.

doi: 10.3899/jrheum.180226. Epub 2018 Nov 1.

Does Rheumatoid Arthritis Really Improve During Pregnancy? A Systematic Review and Metaanalysis

Hannah Jethwa^{1

2}, Suzanne Lam^{3

4}, Colette Smith^{3

4}, Ian Giles^{3

4}

Affiliations

¹ From the Rheumatology Department, London North West Healthcare National Health Service (NHS) Trust; General Medicine, Croydon University Hospital; Statistics Department, Royal Free Hospital; Centre for Rheumatology Research, Rayne Institute, University College London, London, UK. hannahjethwa@nhs.net.
² H. Jethwa, Specialist Registrar in Rheumatology, BSc, MBChB, MRCP, Rheumatology Department, London North West Healthcare NHS Trust; S. Lam, General Practitioner Trainee, BSc, MBBS, General Medicine, Croydon University Hospital; C. Smith, Research Statistician, PhD, Statistics Department, Royal Free Hospital; I. Giles, Consultant Rheumatologist, PhD, FRCP, Centre for Rheumatology Research, Rayne Institute, University College London. hannahjethwa@nhs.net.
³ From the Rheumatology Department, London North West Healthcare National Health Service (NHS) Trust; General Medicine, Croydon University Hospital; Statistics Department, Royal Free Hospital; Centre for Rheumatology Research, Rayne Institute, University College London, London, UK.
⁴ H. Jethwa, Specialist Registrar in Rheumatology, BSc, MBChB, MRCP, Rheumatology Department, London North West Healthcare NHS Trust; S. Lam, General Practitioner Trainee, BSc, MBBS, General Medicine, Croydon University Hospital; C. Smith, Research Statistician, PhD, Statistics Department, Royal Free Hospital; I. Giles, Consultant Rheumatologist, PhD, FRCP, Centre for Rheumatology Research, Rayne Institute, University College London.

PMID: 30385703
DOI: 10.3899/jrheum.180226

Meta-Analysis

Does Rheumatoid Arthritis Really Improve During Pregnancy? A Systematic Review and Metaanalysis

Hannah Jethwa et al. J Rheumatol. 2019 Mar.

. 2019 Mar;46(3):245-250.

doi: 10.3899/jrheum.180226. Epub 2018 Nov 1.

Authors

Hannah Jethwa^{1

2}, Suzanne Lam^{3

4}, Colette Smith^{3

4}, Ian Giles^{3

4}

Affiliations

¹ From the Rheumatology Department, London North West Healthcare National Health Service (NHS) Trust; General Medicine, Croydon University Hospital; Statistics Department, Royal Free Hospital; Centre for Rheumatology Research, Rayne Institute, University College London, London, UK. hannahjethwa@nhs.net.
² H. Jethwa, Specialist Registrar in Rheumatology, BSc, MBChB, MRCP, Rheumatology Department, London North West Healthcare NHS Trust; S. Lam, General Practitioner Trainee, BSc, MBBS, General Medicine, Croydon University Hospital; C. Smith, Research Statistician, PhD, Statistics Department, Royal Free Hospital; I. Giles, Consultant Rheumatologist, PhD, FRCP, Centre for Rheumatology Research, Rayne Institute, University College London. hannahjethwa@nhs.net.
³ From the Rheumatology Department, London North West Healthcare National Health Service (NHS) Trust; General Medicine, Croydon University Hospital; Statistics Department, Royal Free Hospital; Centre for Rheumatology Research, Rayne Institute, University College London, London, UK.
⁴ H. Jethwa, Specialist Registrar in Rheumatology, BSc, MBChB, MRCP, Rheumatology Department, London North West Healthcare NHS Trust; S. Lam, General Practitioner Trainee, BSc, MBBS, General Medicine, Croydon University Hospital; C. Smith, Research Statistician, PhD, Statistics Department, Royal Free Hospital; I. Giles, Consultant Rheumatologist, PhD, FRCP, Centre for Rheumatology Research, Rayne Institute, University College London.

PMID: 30385703
DOI: 10.3899/jrheum.180226

Abstract

Objective: We performed a systematic review and metaanalysis to assess rheumatoid arthritis (RA) disease activity during pregnancy using objective disease activity scoring systems.

Methods: A systematic review of PubMed, EMBASE/Medline, Cochrane, and LactMed databases was performed. Our inclusion criteria for analysis were prospective studies, more than 5 patients per study, and data on RA using an objective scoring system conducted by a clinician/health professional.

Results: Ten studies were eligible for final analysis, which included 237 patients, of which prepartum data were available for 204 patients. Postpartum disease activity was recorded in 135 pregnancies.

Conclusion: Disease activity improved in 60% of patients with RA in pregnancy and flared in 46.7% postpartum.

Keywords: DISEASE ACTIVITY; INFLAMMATORY ARTHRITIS; PREGNANCY; PROSPECTIVE; RHEUMATOID ARTHRITIS.

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Comment in

It Is Time to Modify Treatment to Enable More Women with Rheumatoid Arthritis to Have Successful Pregnancies.
Clowse MEB. Clowse MEB. J Rheumatol. 2019 Mar;46(3):223-225. doi: 10.3899/jrheum.181036. J Rheumatol. 2019. PMID: 30824666 No abstract available.

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Does Rheumatoid Arthritis Really Improve During Pregnancy? A Systematic Review and Metaanalysis

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Does Rheumatoid Arthritis Really Improve During Pregnancy? A Systematic Review and Metaanalysis

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