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. 2019 May;22(2):244-251.
doi: 10.1038/s41391-018-0105-2. Epub 2018 Nov 1.

Higher baseline dietary fat and fatty acid intake is associated with increased risk of incident prostate cancer in the SABOR study

Michael A Liss  1   2 , Osamah Al-Bayati  3 , Jonathan Gelfond  4 , Martin Goros  4 , Sarah Ullevig  5 , John DiGiovanni  6 , Jill Hamilton-Reeves  7 , Denise O'Keefe  3 , Dean Bacich  3 , Brandi Weaver  3 , Robin Leach  3   8 , Ian M Thompson  9
Affiliations

Higher baseline dietary fat and fatty acid intake is associated with increased risk of incident prostate cancer in the SABOR study

Michael A Liss et al. Prostate Cancer Prostatic Dis. 2019 May.

Abstract

Background: To study the association of nutrient intake measured by baseline food frequency questionnaire and risk of subsequent prostate cancer (PCa) in the SABOR (San Antonio Biomarkers of Risk) cohort study.

Methods: After IRB approval, more than 1903 men enrolled in a prospective cohort from 2000 to 2010 as part of the SABOR clinical validation site for the National Cancer Institute Early Detection Research Network. Food and nutrient intakes were calculated using a Food Frequency Questionnaire. Cox proportional hazards modeling and covariate-balanced propensity scores were used to assess the associations between all nutrients and PCa.

Results: A total of 229 men were diagnosed with PCa by prostate biopsy. Among all nutrients, increased risk of PCa was associated with intake of dietary fat scaled by the total caloric intake, particularly saturated fatty acid (SFA) [HR 1.19; 95% CI, 1.07-1.32), P value < 0.001, False discovery rate (FDR) 0.047] and trans fatty acid (TFA) [HR per quintile 1.21; (95% CI) (1.08-1.35), P < 0.001, FDR 0.039]. There was an increased risk of PCa with increasing intake of monounsaturated fatty acid (MUFA) (HR per quintile 1.14; 95% CI 1.03-1.27, P = 0.01, FDR 0.15) and cholesterol [HR per quintile 1.13; 95% confidence interval (95% CI) (1.02-1.26), P-value 0.02, FDR 0.19].

Conclusion: After examining a large, population-based cohort for PCa diagnosis, we identified dietary total fat and certain fatty acids as associated with increased risk of PCa. We found no factors that were protective from PCa. Dietary modification of fatty acid intake may reduce risk of PCa.

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Conflict of interest statement

Conflict of interest The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Study cohort diagram. The flow diagram recommended for cohort studies utilizing STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) recommendations. FFQ Food Frequency Questionnaire, PCa prostate cancer, ISUP International Society of Urologic Pathologists
Fig. 2
Fig. 2
Volcano plot for scaled nutrients of the food frequency questionnaire on prostate cancer risk. The horizontal axis (log2 HR) is the log hazard ratio and the vertical axis (–log10 P-value) is the log P-value
Fig. 3
Fig. 3
Cox proportional hazard mode for time to prostate cancer based on SFA 18:0 (stearic acid) intake quintile. SFA 18:0 quintiles 1 and 5 are the bottom 20th and top 20th percentiles, respectively
See this image and copyright information in PMC

Comment in

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