[Effect of collagenase on neuromuscular transmission in the frog]

Abstract

Modification of synaptic function was estimated through the action of 0.1% solution of collagenase on neuromuscular junction in frog. Electrophysiological experiments revealed a decrease of the e.p.p. quantum content on single nerve stimulation with collagenase. The latter or the product of its splitting modify the action zones of mediator secretion. The demyelination action of collagenase on nerve is discussed.