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Case Reports
. 2018 Oct 24;14(1):97-102.
doi: 10.1016/j.radcr.2018.09.029. eCollection 2019 Jan.

Squamous cell carcinoma arising in a partially ruptured giant mature cystic teratoma: A case report

Jean Sebastein Rowe  1 , Gabriel Makar  2 , Thomas Holdbrook  3 , Pauline Germaine  1
Affiliations
Case Reports

Squamous cell carcinoma arising in a partially ruptured giant mature cystic teratoma: A case report

Jean Sebastein Rowe et al. Radiol Case Rep. .

Abstract

Mature cystic teratomas are the most common ovarian germ cell tumors and represent 70% of the benign ovarian tumors occurring in women under age 30. In less than 2% of cases, these tumors can transform into malignancies. Squamous cell carcinoma arises most frequently from these tumors (in 80% of cases). Intra-peritoneal rupture accounts for approximately 1%-2% of cystic teratoma complications with most ruptures occurring either intraoperatively during laparoscopic surgery or due to trauma. This case report describes the common presentation, imaging, and pathologic findings of a mature cystic teratoma with 2 uncommon associated complications.

Keywords: Malignant transformation; Mature ovarian teratoma; Ovarian germ cell tumor; Ovarian squamous cell cancer; Rupture.

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Figures

Fig. 1
Fig. 1
Contrast-enhanced computed tomography images: (A) through (F) – Coronal, axial, and sagittal CT images demonstrating features of MCT with internal fat/fluid level (blue arrow) and a separate smaller mass suspended within it (red arrow). Right labial Bartholin gland cyst is noted on Image A (orange arrow); (D–F) – Axial, sagittal, and coronal CT images demonstrate droplets of fat (green arrow) separate from the dominant mass with adjacent stranding and ascites (purple arrow) suggesting rupture and corresponding with lipogranulomatous reaction on histology. (Color version of this figure is available online.)
Fig. 2
Fig. 2
Microscopic Images: (A) – Dermoid cyst. Cyst lining with keratinized epidermis, associated adnexal structures (sebaceous glands and hair follicle), and smooth muscle (H and E, ×100); (B) – Dermoid cyst. Characteristic lipogranulomatous reaction in cyst wall (H and E, ×200); (C) – Squamous cell carcinoma in situ arising in cyst lining. There is full thickness squamous epithelial atypia characterized by enlarged, hyperchromatic nuclei and increased mitotic activity (H and E, ×400); (D) – Invasive squamous cell carcinoma with necrosis (right) (H and E, ×200); (E) – Squamous cell carcinoma with lymphovascular invasion (H and E, ×100).
See this image and copyright information in PMC

References

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