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Review
. 2018 Oct 27;10(10):670-684.
doi: 10.4254/wjh.v10.i10.670.

Era of direct acting anti-viral agents for the treatment of hepatitis C

Affiliations
Review

Era of direct acting anti-viral agents for the treatment of hepatitis C

Monjur Ahmed. World J Hepatol. .

Abstract

Hepatitis C infection is universal and the most common indication of liver transplantation in the United States. The period of less effective interferon therapy with intolerable side effects has gone. Now we have stepped into the era of direct acting anti-viral agents (DAAs) against hepatitis C virus. Treatment of hepatitis C is now extremely effective, tolerable and requires a short duration of intake of oral agents. Less monitoring is required with the current therapy and drug-drug interactions are less than the previous regimen. The current treatment options of chronic hepatitis C with various DAAs are discussed in this article.

Keywords: Direct acting anti-viral agents; Hepatitis C virus infection; Hepatitis C virus/human immunodeficiency virus co-infection; Post-liver transplant.

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Conflict of interest statement

Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.

Figures

Figure 1
Figure 1
Hepatitis C virus RNA (genome).

References

    1. Petruzziello A, Marigliano S, Loquercio G, Cozzolino A, Cacciapuoti C. Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus genotypes. World J Gastroenterol. 2016;22:7824–7840. - PMC - PubMed
    1. Pawlotsky JM. NS5A inhibitors in the treatment of hepatitis C. J Hepatol. 2013;59:375–382. - PubMed
    1. Ogata N, Alter HJ, Miller RH, Purcell RH. Nucleotide sequence and mutation rate of the H strain of hepatitis C virus. Proc Natl Acad Sci USA. 1991;88:3392–3396. - PMC - PubMed
    1. Pawlotsky JM. Hepatitis C virus population dynamics during infection. Curr Top Microbiol Immunol. 2006;299:261–284. - PubMed
    1. Myers RP, Regimbeau C, Thevenot T, Leroy V, Mathurin P, Opolon P, Zarski JP, Poynard T. Interferon for interferon naive patients with chronic hepatitis C. Cochrane Database Syst Rev. 2002;(2):CD000370. - PMC - PubMed