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. 2018 Oct 10;5(10):ofy258.
doi: 10.1093/ofid/ofy258. eCollection 2018 Oct.

Impact of a Multiplex PCR Assay for Bloodstream Infections With and Without Antimicrobial Stewardship Intervention at a Cancer Hospital

Brian A Buss  1 , Timothy J Baures  2 , Minkyoung Yoo  3 , Kimberly E Hanson  4   5 , Donald P Alexander  6   7 , Russell J Benefield  6   7 , Emily S Spivak  4   8
Affiliations

Impact of a Multiplex PCR Assay for Bloodstream Infections With and Without Antimicrobial Stewardship Intervention at a Cancer Hospital

Brian A Buss et al. Open Forum Infect Dis. .

Abstract

Implementation of Biofire FilmArray Blood Culture Identification Multiplex PCR panel (BCID) at a cancer hospital was associated with reduced time to appropriate antimicrobial therapy. Additional reductions were not observed when BCID was coupled with antimicrobial stewardship intervention.

Keywords: antimicrobial stewardship; hematopoietic stem cell transplant; immunocompromised host; molecular-based rapid diagnostic testing; neutropenic fever.

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Figures

Figure 1.
Figure 1.
Flow diagram for participants included in the study. Unadjusted mean time to appropriate antimicrobial therapy using a 1-way analysis of variance test as a comparison: no statistical difference in uncontrolled means between PRE, POST, and POST-AS groups (44 hours, 25 hours, 26 hours; P = .069) at an alpha = .05 level. Abbreviations: BCID, multiplex polymerase chain reaction–based blood culture identification; BSI, bloodstream infection; PRE, before BCID implementation; OSH, outside hospital; POST, after BCID implementation; POST-AS, BCID coupled with antimicrobial stewardship.
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