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Comparative Study
. 2018 Oct;59(10):528-533.
doi: 10.11622/smedj.2018127.

A comparison of Streptococcus agalactiae septic arthritis and non-Streptococcus agalactiae septic arthritis

Victor Tzong Jing Wang  1 , Jiong Hao Tan  1 , Leon Han Pay  1 , Tianyi Wu  1 , Liang Shen  2 , Gavin Kane O'Neill  1 , Veerasingam Prem Kumar  1
Affiliations
Comparative Study

A comparison of Streptococcus agalactiae septic arthritis and non-Streptococcus agalactiae septic arthritis

Victor Tzong Jing Wang et al. Singapore Med J. 2018 Oct.

Abstract

Introduction: Streptococcus agalactiae (Group B Streptococcus, GBS) is an uncommon cause of septic arthritis in the adult population. In recent years, there has been an increase in the incidence of GBS septic arthritis. This study aims to compare the clinical presentation, investigations, microbiology and outcome of management in patients with GBS and non-GBS septic arthritis.

Methods: Retrospective review of hospital surgical records was done to identify all patients treated surgically at our institution from January 2011 to January 2016 for primary septic arthritis. Patients were categorised into two groups: those with culture-proven GBS septic arthritis and those with causative pathogens that were not GBS. Patients who were medically unfit for surgical intervention as well as those who declined interventional procedures were excluded from the study.

Results: A total of 83 patients were included in the study: 62 (74.7%) had non-GBS septic arthritis and 21 (25.3%) had GBS septic arthritis. Patients with GBS septic arthritis were more likely to have polyarticular involvement (p < 0.001) and involvement of less common sites such as the elbow joint. They were also more likely to have elevated inflammatory markers (C-reactive protein > 150 mg/L; p = 0.017) and positive blood cultures (p = 0.02), and were typically healthy adults with no medical comorbidities (p = 0.012).

Conclusion: Patients with GBS septic arthritis were more likely to present with polyarticular involvement, positive blood cultures and higher levels of C-reactive protein on admission, and tended to be healthier individuals with no medical comorbidities.

Keywords: Group B Streptococcus; Streptococcus agalactiae; bacterial infection; polyarticular; septic arthritis.

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References

    1. Gupta MN, Sturrock RD, Field M. A prospective 2-year study of 75 patients with adult-onset septic arthritis. Rheumatology (Oxford) 2001;40:24–30. - PubMed
    1. Weston VC, Jones AC, Bradbury N, Fawthrop F, Doherty M. Clinical features and outcome of septic arthritis in a single UK Health District 1982-1991. Ann Rheum Dis. 1999;58:214–9. - PMC - PubMed
    1. Dubost JJ, Soubrier M, De Champs C, et al. No changes in the distribution of organisms responsible for septic arthritis over a 20 year period. Ann Rheum Dis. 2002;61:267–9. - PMC - PubMed
    1. Le Dantec L, Maury F, Flipo RM, et al. Peripheral pyogenic arthritis. A study of one hundred seventy-nine cases. Rev Rhum Engl Ed. 1996;63:103–10. - PubMed
    1. Kothari NJ, Morin CA, Glennen A, et al. Invasive group B streptococcal disease in the elderly, Minnesota, USA 2003-2007. Emerg Infect Dis. 2009;15:1279–81. - PMC - PubMed

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