Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Aug;76(4):332-6.
doi: 10.1007/BF00272440.

Absence of Y-specific DNA sequences in human 46,XX true hermaphrodites and in 45,X mixed gonadal dysgenesis

F Waibel, G Scherer, M Fraccaro, T W Hustinx, J Weissenbach, J Wieland, A Mayerová, E Back, U Wolf

Absence of Y-specific DNA sequences in human 46,XX true hermaphrodites and in 45,X mixed gonadal dysgenesis

F Waibel et al. Hum Genet. 1987 Aug.

Abstract

A search for Y-specific DNA sequences has been performed in a sample of seven 46,XX true hermaphrodites and one 45,X mixed gonadal dysgenesis case and compared with a sample of 11 XX males. Using six Y-specific DNA probes no hybridization signal was obtained in the hermaphrodite group; in contrast, all XX males gave a positive signal with at least one probe. This difference is statistically highly significant. We conclude that the aetiology of true hermaphroditism is different from that of the XX male syndrome. As all cases of the hermaphrodite group are positive for the serological sex-specific antigen (Sxs) it is concluded that this antigen can be present even in the absence of Y-specific DNA.

PubMed Disclaimer

References

    1. Hum Genet. 1985;71(2):150-4 - PubMed
    1. J Exp Med. 1978 Jul 1;148(1):58-70 - PubMed
    1. Transplantation. 1985 Jun;39(6):634-8 - PubMed
    1. Differentiation. 1981;18(3):161-8 - PubMed
    1. Am J Hum Genet. 1984 Mar;36(2):265-76 - PubMed

Publication types

LinkOut - more resources