Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2018 Jul-Aug;56(212):745-748.
doi: 10.31729/jnma.3704.

Efficacy of Use of Triamcinolone Ointment for Clean Intermittent Self Catheterization following Internal Urethrotomy

Sunil Regmi  1 , Sunil Chandra Adhikari  2 , Saroj Yadav  2 , Rabin Raj Singh  2 , Ravi Bastakoti  2
Affiliations
Randomized Controlled Trial

Efficacy of Use of Triamcinolone Ointment for Clean Intermittent Self Catheterization following Internal Urethrotomy

Sunil Regmi et al. JNMA J Nepal Med Assoc. 2018 Jul-Aug.

Abstract

Introduction: Internal urethrotomy is recommended for the treatment of urethral strictures shorter than 1.5 cm but has been associated with high recurrence rates. The aim of this study was to evaluate the efficacy of use of triamcinolone ointment for clean intermittent self catheterization in the prevention of urethral stricture recurrence after internal urethrotomy.

Methods: Total of 60 male patients undergoing internal urethrotomy were assigned into two groups and clean intermittent self catheterization was performed using either triamcinolone ointment or a water-based gel for lubrication of the catheter in this randomized clinical trial. Clean intermittent self catheterization regimen was continued for 6 months and patients were followed for 12 months. Urethrocystoscopic evaluation was done 6 and 12 months postoperatively.

Results: The recurrence rates were compared between the two groups. There were no significant differences in patient characteristics and etiology of the stricture between the two groups. There was a 6 (22.22%) recurrence rate in the patients of the triamcinolone group against 13 (46.42%) in those of the control group after the first internal urethrotomy (P=0.04). After second internal urethrotomy, the urethra was stabilized in 5 (83.3%) of the patients in the triamcinolone group and 8 (61.5%) those in the control group (P=0.05). We also found a significant correlation between recurrence and stricture length (P=0.02) but the time to recurrence was not statistically significant (P=0.16).

Conclusions: The use of triamcinolone ointment in patients on CISC regimen after internal urethrotomy significantly decreased the stricture recurrence rate.

Keywords: clean intermittent self catheterization; internal urethrotomy; Triamcinolone; urethral stricture..

PubMed Disclaimer

Conflict of interest statement

None.

Figures

Figure 1.
Figure 1.. Flow Chart of Patient Selection
See this image and copyright information in PMC

References

    1. Jordan GH, Schlossberg SM. In: Campbell-Walsh Urology. 9th. Wein AJ, Kavoussi LR, Novick AC, editors. Saunders: Philadelphia; 2007. Surgery of Penis and Urethra; pp. 1055–75.
    1. Albers P, Fichtner J, Brühl P, Muller SC. Long-term results of internal urethrotomy. J Urol. 1996 Nov;156(5):1611–4. - PubMed
    1. Steenkamp JW, Heyns CF, Dekock MLS. Internal urethrotomy versus dilation as treatment for male urethral strictures: a prospective, randomized comparison. J Urol. 1997 Jan;157(1):98–101. - PubMed
    1. Naudé AM, Heyns CF. What is the place of internal urethrotomy in the treatment of urethral stricture disease? Nat Clin Pract Urol. 2005 Nov;2(11):538–45. doi: 10.1038/ncpuro0320. - DOI - PubMed
    1. Hebert PW. The treatment of urethral stricture: transurethral injection of triamcinolone. J Urol. 1972;108:745–7. doi: 10.1016/s0022-5347(17)60856-5. - DOI - PubMed

Publication types

LinkOut - more resources