Evolution at the Cutting Edge: CRISPR-Mediated Directed Evolution
- PMID: 30388408
- DOI: 10.1016/j.molcel.2018.10.027
Evolution at the Cutting Edge: CRISPR-Mediated Directed Evolution
Abstract
In a recent issue of Nature, Halperin et al. (2018) develop a new technology to continuously diversify specific genomic loci by combining CRISPR-Cas9 with error-prone DNA polymerases.
Copyright © 2018 Elsevier Inc. All rights reserved.
Comment on
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CRISPR-guided DNA polymerases enable diversification of all nucleotides in a tunable window.Nature. 2018 Aug;560(7717):248-252. doi: 10.1038/s41586-018-0384-8. Epub 2018 Aug 1. Nature. 2018. PMID: 30069054
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