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. 2018 Nov 1;23(5):625-627.
doi: 10.1016/j.stem.2018.10.012.

Mice from Same-Sex Parents: CRISPRing Out the Barriers for Unisexual Reproduction

Ido Sagi  1 , Shiran Bar  1 , Nissim Benvenisty  2
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Mice from Same-Sex Parents: CRISPRing Out the Barriers for Unisexual Reproduction

Ido Sagi et al. Cell Stem Cell. .
Free article

Abstract

Genomic imprinting results in the molecular and functional inequality of maternal and paternal alleles, precluding mammalian unisexual development. In this issue of Cell Stem Cell, Li et al. (2018) employ sophisticated manipulations of gametes and engineered haploid embryonic stem cells to successfully generate both all-maternal and all-paternal mice, effectively overcoming the roadblocks of imprinting.

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